Juliano CE , Swartz SZ , Wessel GM .

T32 GM007601 NIGMS NIH HHS

Agata, Two different evolutionary origins of stem cell systems and their molecular basis. 2006, Pubmed

Agata, Two different evolutionary origins of stem cell systems and their molecular basis. 2006, Pubmed
Agee, Maternal expression of a NANOS homolog is required for early development of the leech Helobdella robusta. 2006, Pubmed
Aravin, A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. 2008, Pubmed
Aravin, The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. 2007, Pubmed
Aravin, A novel class of small RNAs bind to MILI protein in mouse testes. 2006, Pubmed
Asaoka-Taguchi, Maternal Pumilio acts together with Nanos in germline development in Drosophila embryos. 1999, Pubmed
Ball, A simple plan--cnidarians and the origins of developmental mechanisms. 2004, Pubmed
Batista, PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. 2008, Pubmed
Bhat, The posterior determinant gene nanos is required for the maintenance of the adult germline stem cells during Drosophila oogenesis. 1999, Pubmed
Boelsterli, An electron microscopic study of early developmental stages, myogenesis, oogenesis and cnidogenesis in the anthomedusa, Podocoryne carnea M. Sars. 1977, Pubmed
Bosch, Male and female stem cells and sex reversal in Hydra polyps. 1986, Pubmed
Boswell, tudor, a gene required for assembly of the germ plasm in Drosophila melanogaster. 1985, Pubmed
Boyer, Dual origins of mesoderm in a basal spiralian: cell lineage analyses in the polyclad turbellarian Hoploplana inquilina. 1996, Pubmed
Breitwieser, Oskar protein interaction with Vasa represents an essential step in polar granule assembly. 1996, Pubmed
Brennecke, An epigenetic role for maternally inherited piRNAs in transposon silencing. 2008, Pubmed
Brower-Toland, Drosophila PIWI associates with chromatin and interacts directly with HP1a. 2007, Pubmed
Brown, Early lineage specification of long-lived germline precursors in the colonial ascidian Botryllus schlosseri. 2009, Pubmed
Carmell, MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. 2007, Pubmed
Carrera, VASA mediates translation through interaction with a Drosophila yIF2 homolog. 2000, Pubmed
Chera, Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype. 2006, Pubmed
Chuma, Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. 2006, Pubmed
Ciosk, Translational regulators maintain totipotency in the Caenorhabditis elegans germline. 2006, Pubmed
Cox, A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal. 1998, Pubmed
Crittenden, A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans. 2002, Pubmed
Dalby, Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila. 1993, Pubmed
David, Characterization of interstitial stem cells in hydra by cloning. 1977, Pubmed
De Mulder, Stem cells are differentially regulated during development, regeneration and homeostasis in flatworms. 2009, Pubmed
DeSalle, An even "newer" animal phylogeny. 2008, Pubmed
Deng, miwi, a murine homolog of piwi, encodes a cytoplasmic protein essential for spermatogenesis. 2002, Pubmed
Deshpande, Nanos downregulates transcription and modulates CTD phosphorylation in the soma of early Drosophila embryos. 2005, Pubmed
Dunn, Broad phylogenomic sampling improves resolution of the animal tree of life. 2008, Pubmed
Eberhart, Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia. 1996, Pubmed
Ettensohn, The invertebrate deuterostomes: an introduction to their phylogeny, reproduction, development, and genomics. 2004, Pubmed
Ewen-Campen, The molecular machinery of germ line specification. 2010, Pubmed
Extavour, Evolution of the bilaterian germ line: lineage origin and modulation of specification mechanisms. 2007, Pubmed
Extavour, Mechanisms of germ cell specification across the metazoans: epigenesis and preformation. 2003, Pubmed
Extavour, vasa and nanos expression patterns in a sea anemone and the evolution of bilaterian germ cell specification mechanisms. 2005, Pubmed
Fabioux, Oyster vasa-like gene as a marker of the germline cell development in Crassostrea gigas. 2004, Pubmed
Findley, Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage. 2003, Pubmed
Fischer, The polychaete Platynereis dumerilii (Annelida): a laboratory animal with spiralian cleavage, lifelong segment proliferation and a mixed benthic/pelagic life cycle. 2004, Pubmed
Forbes, Nanos and Pumilio have critical roles in the development and function of Drosophila germline stem cells. 1998, Pubmed
Fujii, Role of the nanos homolog during sea urchin development. 2009, Pubmed , Echinobase
Fukuyama, C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline. 2006, Pubmed
Funayama, Piwi expression in archeocytes and choanocytes in demosponges: insights into the stem cell system in demosponges. 2010, Pubmed
Funayama, The stem cell system in demosponges: insights into the origin of somatic stem cells. 2010, Pubmed
Galliot, Hydra, a niche for cell and developmental plasticity. 2006, Pubmed
Gao, Transfer of a large gene regulatory apparatus to a new developmental address in echinoid evolution. 2008, Pubmed , Echinobase
Genikhovich, The starlet sea anemone Nematostella vectensis: an anthozoan model organism for studies in comparative genomics and functional evolutionary developmental biology. 2009, Pubmed
Grivna, A novel class of small RNAs in mouse spermatogenic cells. 2006, Pubmed
Grivna, MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. 2006, Pubmed
Guan, Pluripotency of spermatogonial stem cells from adult mouse testis. 2006, Pubmed
Guo, A Bruno-like gene is required for stem cell maintenance in planarians. 2006, Pubmed
Gustafson, Post-translational regulation by gustavus contributes to selective Vasa protein accumulation in multipotent cells during embryogenesis. 2011, Pubmed , Echinobase
Haraguchi, nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. 2003, Pubmed
Hashimoto, Bruno-like protein is localized to zebrafish germ plasm during the early cleavage stages. 2006, Pubmed
Hashimoto, Germ cell specific protein VASA is over-expressed in epithelial ovarian cancer and disrupts DNA damage-induced G2 checkpoint. 2008, Pubmed
Hay, Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. 1990, Pubmed
Hay, A protein component of Drosophila polar granules is encoded by vasa and has extensive sequence similarity to ATP-dependent helicases. 1988, Pubmed
Hayashi, Nanos suppresses somatic cell fate in Drosophila germ line. 2004, Pubmed
Holder, Phylogeny estimation: traditional and Bayesian approaches. 2003, Pubmed
Houston, A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus. 2000, Pubmed
Houwing, A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. 2007, Pubmed
Illmensee, Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the egg. 1974, Pubmed
Illmensee, The autonomous function of germ plasm in a somatic region of the Drosophila egg. 1976, Pubmed
Inoue, Germ Cell Differentiation in Starfish: The Posterior Enterocoel as the Origin of Germ Cells in Asterina pectinifera: (starfish/germ cells/PGC/posterior enterocoel/haemal sinus). 1992, Pubmed , Echinobase
Irish, The Drosophila posterior-group gene nanos functions by repressing hunchback activity. 1989, Pubmed
Johnson, Expression of axolotl DAZL RNA, a marker of germ plasm: widespread maternal RNA and onset of expression in germ cells approaching the gonad. 2001, Pubmed
Johnson, Regulative germ cell specification in axolotl embryos: a primitive trait conserved in the mammalian lineage. 2003, Pubmed
Johnstone, Interaction with eIF5B is essential for Vasa function during development. 2004, Pubmed
Jongens, Germ cell-less encodes a cell type-specific nuclear pore-associated protein and functions early in the germ-cell specification pathway of Drosophila. 1994, Pubmed
Jongens, The germ cell-less gene product: a posteriorly localized component necessary for germ cell development in Drosophila. 1992, Pubmed
Juliano, Nanos functions to maintain the fate of the small micromere lineage in the sea urchin embryo. 2010, Pubmed , Echinobase
Juliano, Germ line determinants are not localized early in sea urchin development, but do accumulate in the small micromere lineage. 2006, Pubmed , Echinobase
Juliano, An evolutionary transition of Vasa regulation in echinoderms. 2009, Pubmed , Echinobase
Kadyrova, Translational control of maternal Cyclin B mRNA by Nanos in the Drosophila germline. 2007, Pubmed
Kalmykova, Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. 2005, Pubmed
Kang, Maternal and zygotic expression of a nanos-class gene in the leech Helobdella robusta: primordial germ cells arise from segmental mesoderm. 2002, Pubmed
Karashima, Caenorhabditis elegans homologue of the human azoospermia factor DAZ is required for oogenesis but not for spermatogenesis. 2000, Pubmed
Kee, Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. 2009, Pubmed
Kim-Ha, Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential. 1995, Pubmed
Kimura, Mouse germ cell-less as an essential component for nuclear integrity. 2003, Pubmed
Klattenhoff, Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. 2007, Pubmed
Kobayashi, Essential role of the posterior morphogen nanos for germline development in Drosophila. 1996, Pubmed
Kranz, Identifying the germline in an equally cleaving mollusc: Vasa and Nanos expression during embryonic and larval development of the vetigastropod Haliotis asinina. 2010, Pubmed
Kugler, Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. 2010, Pubmed
Kuramochi-Miyagawa, DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes. 2008, Pubmed
Kuramochi-Miyagawa, MVH in piRNA processing and gene silencing of retrotransposons. 2010, Pubmed
Kuramochi-Miyagawa, Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. 2004, Pubmed
Kuznicki, Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans. 2000, Pubmed
Köprunner, A zebrafish nanos-related gene is essential for the development of primordial germ cells. 2001, Pubmed
Lambert, Mesoderm in spiralians: the organizer and the 4d cell. 2008, Pubmed
Lasko, Posterior localization of vasa protein correlates with, but is not sufficient for, pole cell development. 1990, Pubmed
Lawson, Clonal analysis of the origin of primordial germ cells in the mouse. 1994, Pubmed
Leatherman, germ cell-less acts to repress transcription during the establishment of the Drosophila germ cell lineage. 2002, Pubmed
Leatherman, Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. 2000, Pubmed
Lee, Stem-cell protein Piwil2 is widely expressed in tumors and inhibits apoptosis through activation of Stat3/Bcl-XL pathway. 2006, Pubmed
Lim, Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster. 2007, Pubmed
Lin, Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice. 2005, Pubmed
Lin, A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. 1997, Pubmed
Liu, Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. 2006, Pubmed
Lohmann, Silencing of developmental genes in Hydra. 1999, Pubmed
Markussen, Translational control of oskar generates short OSK, the isoform that induces pole plasma assembly. 1995, Pubmed
Matsui, Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 1992, Pubmed
Megosh, The role of PIWI and the miRNA machinery in Drosophila germline determination. 2006, Pubmed
Mochizuki, Universal occurrence of the vasa-related genes among metazoans and their germline expression in Hydra. 2001, Pubmed
Mochizuki, Expression and evolutionary conservation of nanos-related genes in Hydra. 2000, Pubmed
Müller, Totipotent migratory stem cells in a hydroid. 2004, Pubmed
Nakahata, Biochemical identification of Xenopus Pumilio as a sequence-specific cyclin B1 mRNA-binding protein that physically interacts with a Nanos homolog, Xcat-2, and a cytoplasmic polyadenylation element-binding protein. 2001, Pubmed
Nakahata, Involvement of Xenopus Pumilio in the translational regulation that is specific to cyclin B1 mRNA during oocyte maturation. 2003, Pubmed
Nakamura, Less is more: specification of the germline by transcriptional repression. 2008, Pubmed
Nakano, Larval stages of a living sea lily (stalked crinoid echinoderm). 2003, Pubmed , Echinobase
Newmark, Germ cell specification and regeneration in planarians. 2008, Pubmed
Newmark, Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. 2000, Pubmed
O'Donnell, Mighty Piwis defend the germline against genome intruders. 2007, Pubmed
Palakodeti, The PIWI proteins SMEDWI-2 and SMEDWI-3 are required for stem cell function and piRNA expression in planarians. 2008, Pubmed
Parisi, The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis. 1999, Pubmed
Pehrson, The fate of the small micromeres in sea urchin development. 1986, Pubmed , Echinobase
Peterson, Set-aside cells in maximal indirect development: evolutionary and developmental significance. 1997, Pubmed
Peterson, Animal phylogeny and the ancestry of bilaterians: inferences from morphology and 18S rDNA gene sequences. 2001, Pubmed
Pfister, Flatworm stem cells and the germ line: developmental and evolutionary implications of macvasa expression in Macrostomum lignano. 2008, Pubmed
Pilon, A nanos homolog in leech. 1997, Pubmed
Qiao, Molecular characterization of hiwi, a human member of the piwi gene family whose overexpression is correlated to seminomas. 2002, Pubmed
RALPH, Tetraplatia, a coronate scyphomedusan. 1960, Pubmed
Rabinowitz, Nanos is required in somatic blast cell lineages in the posterior of a mollusk embryo. 2008, Pubmed
Raff, Origins of the other metazoan body plans: the evolution of larval forms. 2008, Pubmed
Ransick, Postembryonic segregation of the germ line in sea urchins in relation to indirect development. 1996, Pubmed , Echinobase
Rebscher, The germ plasm component Vasa allows tracing of the interstitial stem cells in the cnidarian Hydractinia echinata. 2008, Pubmed
Rebscher, Vasa unveils a common origin of germ cells and of somatic stem cells from the posterior growth zone in the polychaete Platynereis dumerilii. 2007, Pubmed
Reddien, SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells. 2005, Pubmed
Reijo, Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. 1995, Pubmed
Richardson, Mechanisms guiding primordial germ cell migration: strategies from different organisms. 2010, Pubmed
Rokas, Animal evolution and the molecular signature of radiations compressed in time. 2005, Pubmed
Rouhana, Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance. 2010, Pubmed
Ruggiu, The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. 1997, Pubmed
Sada, The RNA-binding protein NANOS2 is required to maintain murine spermatogonial stem cells. 2009, Pubmed
Saito, Specific association of Piwi with rasiRNAs derived from retrotransposon and heterochromatic regions in the Drosophila genome. 2006, Pubmed
Salvetti, DjPum, a homologue of Drosophila Pumilio, is essential to planarian stem cell maintenance. 2005, Pubmed
Sato, Maternal Nanos represses hid/skl-dependent apoptosis to maintain the germ line in Drosophila embryos. 2007, Pubmed
Schaner, A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. 2003, Pubmed
Schupbach, Germline autonomy of maternal-effect mutations altering the embryonic body pattern of Drosophila. 1986, Pubmed
Seipel, The germ line and somatic stem cell gene Cniwi in the jellyfish Podocoryne carnea. 2004, Pubmed
Seki, Cellular dynamics associated with the genome-wide epigenetic reprogramming in migrating primordial germ cells in mice. 2007, Pubmed
Shamblott, Derivation of pluripotent stem cells from cultured human primordial germ cells. 1998, Pubmed
Sharma, Human CD34(+) stem cells express the hiwi gene, a human homologue of the Drosophila gene piwi. 2001, Pubmed
Shibata, Expression of vasa(vas)-related genes in germline cells and totipotent somatic stem cells of planarians. 1999, Pubmed
Sly, Who came first--larvae or adults? origins of bilaterian metazoan larvae. 2003, Pubmed
Solana, Spoltud-1 is a chromatoid body component required for planarian long-term stem cell self-renewal. 2009, Pubmed
Soper, Mouse maelstrom, a component of nuage, is essential for spermatogenesis and transposon repression in meiosis. 2008, Pubmed
Spike, Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteins. 2008, Pubmed
Strome, Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegans. 1982, Pubmed
Styhler, vasa is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst development. 1998, Pubmed
Styhler, VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS. 2002, Pubmed
Su, The cell cycle program in germ cells of the Drosophila embryo. 1998, Pubmed
Subramaniam, nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. 1999, Pubmed
Suzuki, Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. 2008, Pubmed
Swartz, Localization of Vasa mRNA during early cleavage of the snail Ilyanassa. 2008, Pubmed
Sánchez Alvarado, Double-stranded RNA specifically disrupts gene expression during planarian regeneration. 1999, Pubmed
Takamura, Primordial germ cells originate from the endodermal strand cells in the ascidian Ciona intestinalis. 2002, Pubmed
Tam, The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo. 1996, Pubmed
Tanaka, The mouse homolog of Drosophila Vasa is required for the development of male germ cells. 2000, Pubmed
Tanaka, Study of the Lineage and Cell Cycle of Small Micromeres in Embryos of the Sea Urchin, Hemicentrotus pulcherrimus: (small micromeres/cell cycle/cell lineage/unequal cleavage/sea urchin). 1990, Pubmed , Echinobase
Thomson, Drosophila tudor is essential for polar granule assembly and pole cell specification, but not for posterior patterning. 2004, Pubmed
Tomancak, Oocyte polarity depends on regulation of gurken by Vasa. 1998, Pubmed
Tsuda, Conserved role of nanos proteins in germ cell development. 2003, Pubmed
Unhavaithaya, MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. 2009, Pubmed
Vagin, A distinct small RNA pathway silences selfish genetic elements in the germline. 2006, Pubmed
Voronina, Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development. 2008, Pubmed , Echinobase
Wang, Nanos maintains germline stem cell self-renewal by preventing differentiation. 2004, Pubmed
Wang, A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. 2008, Pubmed
Wang, nanos function is essential for development and regeneration of planarian germ cells. 2007, Pubmed
Whitington, Quantitative studies of germ plasm and germ cells during early embryogenesis of Xenopus laevis. 1975, Pubmed
Wolke, Multiple levels of posttranscriptional control lead to germ line-specific gene expression in the zebrafish. 2002, Pubmed
Yin, An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster. 2007, Pubmed
Yoon, Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells. 1997, Pubmed