Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2023 Sep 26;2110:. doi: 10.3390/md21100506.
Show Gene links
Show Anatomy links
Mutable Collagenous Tissue Isolated from Echinoderms Leads to the Production of a Dermal Template That Is Biocompatible and Effective for Wound Healing in Rats.
Carolo A
,
Melotti L
,
Zivelonghi G
,
Sacchetto R
,
Akyürek EE
,
Martinello T
,
Venerando A
,
Iacopetti I
,
Sugni M
,
Martinelli G
,
Roncoroni M
,
Marzorati S
,
Barbon S
,
Contran M
,
Incendi D
,
Perozzo F
,
Porzionato A
,
Vindigni V
,
Patruno M
.
Abstract
The mutable collagenous tissue (MCT) of echinoderms possesses biological peculiarities that facilitate native collagen extraction and employment for biomedical applications such as regenerative purposes for the treatment of skin wounds. Strategies for skin regeneration have been developed and dermal substitutes have been used to cover the lesion to facilitate cell proliferation, although very little is known about the application of novel matrix obtained from marine collagen. From food waste we isolated eco-friendly collagen, naturally enriched with glycosaminoglycans, to produce an innovative marine-derived biomaterial assembled as a novel bi-layered skin substitute (Marine Collagen Dermal Template or MCDT). The present work carried out a preliminary experimental in vivo comparative analysis between the MCDT and Integra, one of the most widely used dermal templates for wound management, in a rat model of full-thickness skin wounds. Clinical, histological, and molecular evaluations showed that the MCDT might be a valuable tool in promoting and supporting skin wound healing: it is biocompatible, as no adverse reactions were observed, along with stimulating angiogenesis and the deposition of mature collagen. Therefore, the two dermal templates used in this study displayed similar biocompatibility and outcome with focus on full-thickness skin wounds, although a peculiar cellular behavior involving the angiogenesis process was observed for the MCDT.
Badis,
The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep.
2018, Pubmed
Badis,
The effectiveness of platelet-rich plasma on the skin wound healing process: A comparative experimental study in sheep.
2018,
Pubmed
Balasubramani,
Skin substitutes: a review.
2001,
Pubmed
Benedetto,
Production, characterization and biocompatibility of marine collagen matrices from an alternative and sustainable source: the sea urchin Paracentrotus lividus.
2014,
Pubmed
,
Echinobase
Borena,
Regenerative Skin Wound Healing in Mammals: State-of-the-Art on Growth Factor and Stem Cell Based Treatments.
2015,
Pubmed
Borish,
2. Cytokines and chemokines.
2003,
Pubmed
Brem,
Cellular and molecular basis of wound healing in diabetes.
2007,
Pubmed
Bunyaratavej,
Collagen membranes: a review.
2001,
Pubmed
Carmeliet,
Molecular mechanisms and clinical applications of angiogenesis.
2011,
Pubmed
Cervelli,
The use of MatriDerm® and skin grafting in post-traumatic wounds.
2011,
Pubmed
Chocarro-Wrona,
Therapeutic strategies for skin regeneration based on biomedical substitutes.
2019,
Pubmed
Cruz,
Collagen from Marine Sources and Skin Wound Healing in Animal Experimental Studies: a Systematic Review.
2021,
Pubmed
Cuono,
Composite autologous-allogeneic skin replacement: development and clinical application.
1987,
Pubmed
Daneault,
Biological effect of hydrolyzed collagen on bone metabolism.
2017,
Pubmed
Davidson,
Animal models for wound repair.
1998,
Pubmed
Elbialy,
Collagen extract obtained from Nile tilapia (Oreochromis niloticus L.) skin accelerates wound healing in rat model via up regulating VEGF, bFGF, and α-SMA genes expression.
2020,
Pubmed
Ellis,
Recent advances in tissue synthesis in vivo by use of collagen-glycosaminoglycan copolymers.
1996,
Pubmed
Farndale,
Collagen-induced platelet activation.
2006,
Pubmed
Fassini,
Diverse and Productive Source of Biopolymer Inspiration: Marine Collagens.
2021,
Pubmed
Ferrario,
Marine-derived collagen biomaterials from echinoderm connective tissues.
2017,
Pubmed
,
Echinobase
Ferrario,
From Food Waste to Innovative Biomaterial: Sea Urchin-Derived Collagen for Applications in Skin Regenerative Medicine.
2020,
Pubmed
,
Echinobase
Figueres Juher,
[An overview of the beneficial effects of hydrolysed collagen intake on joint and bone health and on skin ageing].
2015,
Pubmed
Fourman,
Laser-assisted indocyanine green dye angiography accurately predicts the split-thickness graft timing of integra artificial dermis.
2014,
Pubmed
Galiano,
Quantitative and reproducible murine model of excisional wound healing.
2004,
Pubmed
Gurtner,
Wound repair and regeneration.
2008,
Pubmed
Hansbrough,
Development of a temporary living skin replacement composed of human neonatal fibroblasts cultured in Biobrane, a synthetic dressing material.
1994,
Pubmed
Harrison,
Platelet activation by collagen provides sustained release of anabolic cytokines.
2011,
Pubmed
Jansen,
The evidence base for the acellular dermal matrix AlloDerm: a systematic review.
2013,
Pubmed
Jones,
A guide to biological skin substitutes.
2002,
Pubmed
Kaasi,
Regenerative collagen biomembrane: Interim results of a Phase I veterinary clinical trial for skin repair.
2018,
Pubmed
Kehrel,
Platelet receptors for collagens.
1995,
Pubmed
Landén,
Transition from inflammation to proliferation: a critical step during wound healing.
2016,
Pubmed
Li,
Vascular smooth muscle cells orchestrate the assembly of type I collagen via alpha2beta1 integrin, RhoA, and fibronectin polymerization.
2003,
Pubmed
Melotti,
A Prototype Skin Substitute, Made of Recycled Marine Collagen, Improves the Skin Regeneration of Sheep.
2021,
Pubmed
,
Echinobase
Menke,
Impaired wound healing.
2007,
Pubmed
Min,
The use of matriderm and autologous skin graft in the treatment of full thickness skin defects.
2014,
Pubmed
Monavarian,
Regenerative Scar-Free Skin Wound Healing.
2019,
Pubmed
Notodihardjo,
A comparison of the wound healing process after the application of three dermal substitutes with or without basic fibroblast growth factor impregnation in diabetic mice.
2020,
Pubmed
Ollivier,
Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI.
2014,
Pubmed
Rahman,
Collagen of Extracellular Matrix from Marine Invertebrates and Its Medical Applications.
2019,
Pubmed
Ramió-Lluch,
Proof of concept of a new autologous skin substitute for the treatment of deep wounds in dogs.
2017,
Pubmed
Riggs,
Outcome of full-thickness skin grafts used to close skin defects involving the distal aspects of the limbs in cats and dogs: 52 cases (2005-2012).
2015,
Pubmed
Rodrigues,
Wound Healing: A Cellular Perspective.
2019,
Pubmed
Rosique,
Curbing Inflammation in Skin Wound Healing: A Review.
2015,
Pubmed
Silva,
Marine origin collagens and its potential applications.
2014,
Pubmed
Sonmez,
Role of platelets in immune system and inflammation.
2017,
Pubmed
Sorg,
Skin Wound Healing: An Update on the Current Knowledge and Concepts.
2017,
Pubmed
Tan,
Promotion of diabetic wound healing by collagen scaffold with collagen-binding vascular endothelial growth factor in a diabetic rat model.
2014,
Pubmed
Theoret,
Tissue engineering in wound repair: the three "R"s--repair, replace, regenerate.
2009,
Pubmed
Wang,
Wound healing.
2018,
Pubmed
Wester,
AlloDerm with split-thickness skin graft for coverage of the forearm free flap donor site.
2014,
Pubmed
Wilkie,
Mutable collagenous tissue: overview and biotechnological perspective.
2005,
Pubmed
,
Echinobase
Zhou,
A Novel Model for Cutaneous Wound Healing and Scarring in the Rat.
2019,
Pubmed
