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Echinobase
ECB-ART-40148
Acta Histochem 2007 Jan 01;1094:338-42. doi: 10.1016/j.acthis.2007.02.004.
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Cyclodextrin, a probe for studying adhesive interactions.

Sajadi S , Rojas P , Oppenheimer SB .


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In this short communication, we introduce alpha-cyclodextrin as a new probe to study mechanisms of adhesive interactions. We show that this cyclic polysaccharide, that consisting of six glucosyl residues linked by alpha-1,4 bonds, was the only sugar of 22 tested that dramatically blocked a specific cellular interaction in the sea urchin embryo (p<0.001 compared with non-sugar controls). A total of 150-400 embryos were sampled for each concentration of each sugar tested. Mechanisms of cellular interactions have been studied for almost a century and they still remain poorly understood. Cyclodextrin is an exciting new tool that can be utilized for investigating these mechanisms.

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Genes referenced: LOC100887844 mgat4c

References [+] :
Akasaka, Scanning electron microscopical study of the inside of sea urchin embryos (Pseudocentotus depressus). Effects of Aryl beta-xyloside, tunicamycin and deprivation of sulfate tions. 1980, Pubmed, Echinobase