Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Nucleic Acids Res
1981 Jul 10;913:3119-28. doi: 10.1093/nar/9.13.3119.
Show Gene links
Show Anatomy links
Vertebrate histone genes: nucleotide sequence of a chicken H2A gene and regulatory flanking sequences.
D'Andrea R
,
Harvey R
,
Wells JR
.
???displayArticle.abstract???
The DNA sequence of a chicken genomal fragment containing a histone H2A gene has been determined. It contains extensive 5'' and 3'' flanking regions and encodes a protein identical in sequence to the histone H2A protein isolated from chicken erythrocytes. In the 5'' flanking region, a possible "TATA box" and three possible "cap sites" can be recognised upstream from the initiation codon. To the 5'' side of the "TATA box" is found an unusual sequence of 21 A''s interrupted by a central G residue. It occupies the same relative position as the P. miliaris H2A gene-specific 5'' dyad symmetry sequence and the "CCAAT box" seen in other eukaryotic polymerase II genes but is clearly different from both. A significant feature of the 3'' non-coding region is the presence of a 23 base-pair sequence that is nearly identical to a conserved region found in sea urchin histone genes. The coding region is extremely GC rich, with strong selection for these bases in the third position of codons. Not a single coding triplet ends in U. No intervening sequences were found in this gene.
Adhya,
Control of transcription termination.
1978, Pubmed
Adhya,
Control of transcription termination.
1978,
Pubmed
Anderson,
A short primer for sequencing DNA cloned in the single-stranded phage vector M13mp2.
1980,
Pubmed
Benoist,
The ovalbumin gene-sequence of putative control regions.
1980,
Pubmed
Busslinger,
A regulatory sequence near the 3' end of sea urchin histone genes.
1979,
Pubmed
,
Echinobase
Busslinger,
Ubiquitous and gene-specific regulatory 5' sequences in a sea urchin histone DNA clone coding for histone protein variants.
1980,
Pubmed
,
Echinobase
Corden,
Promoter sequences of eukaryotic protein-coding genes.
1980,
Pubmed
Efstratiadis,
The structure and evolution of the human beta-globin gene family.
1980,
Pubmed
Grosschedl,
Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo.
1980,
Pubmed
,
Echinobase
Grunstein,
Isolation and sequence analysis of sea urchin (Lytechinus pictus) histone H4 messenger RNA.
1976,
Pubmed
,
Echinobase
Harvey,
Isolation of a genomal clone containing chicken histone genes.
1979,
Pubmed
,
Echinobase
Hentschel,
Sea urchin histone mRNA termini are located in gene regions downstream from putative regulatory sequences.
1980,
Pubmed
,
Echinobase
Kedes,
Histone genes and histone messengers.
1979,
Pubmed
Korn,
Nucleotide sequence of Xenopus borealis oocyte 5S DNA: comparison of sequences that flank several related eucaryotic genes.
1978,
Pubmed
Kozak,
How do eucaryotic ribosomes select initiation regions in messenger RNA?
1978,
Pubmed
Laine,
Primary structure of chicken erythrocyte histone H2A.
1978,
Pubmed
Maxam,
Sequencing end-labeled DNA with base-specific chemical cleavages.
1980,
Pubmed
Proudfoot,
3' non-coding region sequences in eukaryotic messenger RNA.
1976,
Pubmed
Richards,
Molecular cloning and sequence analysis of adult chicken betal globin cDNA.
1979,
Pubmed
Richards,
Chicken globin genes. Nucleotide sequence of cDNA clones coding for the alpha-globin expressed during hemolytic anemia.
1980,
Pubmed
Sanger,
DNA sequencing with chain-terminating inhibitors.
1977,
Pubmed
Sinclair,
Retention of common nucleotide sequences in the ribosomal deoxyribonucleic acid of eukaryotes and some of their physical characteristics.
1971,
Pubmed
