Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-43564
Nat Prod Commun 2014 Jun 01;96:771-2.
Show Gene links Show Anatomy links

Immunomodulatory action of triterpene glycosides isolated from the sea cucumber Actinocucumis typica. Structure-activity relationships.

Pislyagin EA , Aminin DL , Silchenko AS , Avilov SA , Andryjashchenko PV , Kalinin VI , Padmakumar K .


???displayArticle.abstract???
Stimulation of lysosomal activity and ROS formation in mouse peritoneal macrophages by five triterpene glycosides, typicosides A1 (1), A2 (2), B1 (3), C1 (4) and C2 (5) has been studied and compared with their cytotoxic activities. Glycosides 1-3 possess moderate activities, but the most cytotoxic glycoside 5 is not active. Typicoside C1 (4), with low toxicity, was proved to be the most active concerning stimulation of ROS formation. This is the first example of a triterpene glycoside from sea cucumbers with low cytotoxicity, but which demonstrates a strong immunostimulatory effect on mouse peritoneal macrophages in vitro.

???displayArticle.pubmedLink??? 25115075



Genes referenced: LOC100887844 LOC115925116 LOC593824 ros1