Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Eye (Lond)
2019 Aug 01;338:1280-1289. doi: 10.1038/s41433-019-0415-1.
Show Gene links
Show Anatomy links
Membrane patterns in eyes with choroidal neovascularization on optical coherence tomography angiography.
Karacorlu M
,
Sayman Muslubas I
,
Arf S
,
Hocaoglu M
,
Ersoz MG
.
Abstract
BACKGROUND: To evaluate morphologic patterns of choroidal neovascular membranes using optical coherence tomography angiography (OCTA) in patients with treatment-naive, continuously treated, and previously treated exudative age-related macular degeneration (AMD).
SUBJECTS: We assessed retrospectively 184 eyes of 153 patients diagnosed with type 1, type 2, and mixed-type neovascularization associated with AMD. The type of neovascularization and clinical activity were assessed by clinical examination and spectral domain optical coherence tomography (SD-OCT). Morphological patterns of neovascular membranes were categorized using en face images on the AngioVue (Optovue) OCTA system.
RESULTS: The mean age of patients was 77.9 ± 8.6 years (range, 52-96 years). The most frequently identified type of membrane morphology was well-defined in the treatment-naive group (69% of the eyes) and in eyes receiving ongoing anti-VEGF treatments (77% of the eyes). Long-filamentous morphology was the most frequent type in the previously treated group (53%), in which only 33% had a well-defined membrane. All clinically active cases had a well-defined pattern, such as a medusa or sea-fan shaped pattern, or an ill-defined pattern, and none had a long-filamentous neovascular network. Almost half of the clinically inactive cases (47%) had well- or ill-defined, identifiable membrane morphology on OCTA. A long-filamentous membrane pattern, which was consistent with chronicity of lesion, was seen only in eyes with inactive neovascularization.
CONCLUSIONS: The membrane morphology on OCTA was not associated with clinical activity, except that the presence of long dilated filamentous linear vessels was associated with chronicity and lesion inactivity.
Al-Sheikh,
BIOMARKERS OF NEOVASCULAR ACTIVITY IN AGE-RELATED MACULAR DEGENERATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
2018, Pubmed
Al-Sheikh,
BIOMARKERS OF NEOVASCULAR ACTIVITY IN AGE-RELATED MACULAR DEGENERATION USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
2018,
Pubmed
Ambati,
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies.
2003,
Pubmed
Coscas,
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION: A New Diagnostic Challenge.
2015,
Pubmed
El Ameen,
TYPE 2 NEOVASCULARIZATION SECONDARY TO AGE-RELATED MACULAR DEGENERATION IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
2015,
Pubmed
Farecki,
Characteristics of type 1 and 2 CNV in exudative AMD in OCT-Angiography.
2017,
Pubmed
Freund,
Do we need a new classification for choroidal neovascularization in age-related macular degeneration?
2010,
Pubmed
Iafe,
Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration.
2016,
Pubmed
Jung,
The incidence of neovascular subtypes in newly diagnosed neovascular age-related macular degeneration.
2014,
Pubmed
Kuehlewein,
Optical Coherence Tomography Angiography of Type 1 Neovascularization in Age-Related Macular Degeneration.
2015,
Pubmed
Liang,
Optical Coherence Tomography Angiography of Mixed Neovascularizations in Age-Related Macular Degeneration.
2016,
Pubmed
Liang,
CORRELATION OF SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND CLINICAL ACTIVITY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.
2016,
Pubmed
Lumbroso,
LONGITUDINAL OPTICAL COHERENCE TOMOGRAPHY-ANGIOGRAPHY STUDY OF TYPE 2 NAIVE CHOROIDAL NEOVASCULARIZATION EARLY RESPONSE AFTER TREATMENT.
2015,
Pubmed
Lupidi,
Optical coherence tomography angiography in age-related macular degeneration: The game changer.
2018,
Pubmed
Miere,
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF SUBRETINAL FIBROSIS IN AGE-RELATED MACULAR DEGENERATION.
2015,
Pubmed
Miere,
VASCULAR REMODELING OF CHOROIDAL NEOVASCULARIZATION AFTER ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY VISUALIZED ON OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.
2019,
Pubmed
Querques,
Optical Coherence Tomography Angiography Features of Type 3 Neovascularization in Age-Related Macular Degeneration.
2016,
Pubmed
Schmidt-Erfurth,
Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA).
2014,
Pubmed
Souied,
Optical Coherence Tomography Angiography of Type 2 Neovascularization in Age-Related Macular Degeneration.
2016,
Pubmed
Spaide,
Optical Coherence Tomography Angiography Signs of Vascular Abnormalization With Antiangiogenic Therapy for Choroidal Neovascularization.
2015,
Pubmed
Sulzbacher,
Identification and clinical role of choroidal neovascularization characteristics based on optical coherence tomography angiography.
2017,
Pubmed
Sulzbacher,
Diagnostic evaluation of type 2 (classic) choroidal neovascularization: optical coherence tomography, indocyanine green angiography, and fluorescein angiography.
2011,
Pubmed
Xu,
Long-term Progression of Type 1 Neovascularization in Age-related Macular Degeneration Using Optical Coherence Tomography Angiography.
2018,
Pubmed
