Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Medicines (Basel)
2017 May 19;42:. doi: 10.3390/medicines4020031.
Show Gene links
Show Anatomy links
Chemical Composition and In Vitro Cytotoxic and Antimicrobial Activities of the Essential Oil from Leaves of Zanthoxylum monogynum St. Hill (Rutaceae).
Abstract
Background: The Zanthoxylum monogynum species belongs to the family Rutaceae and is found in Southeast, Midwest, and Northeast Brazil. For this genus several biological activities have been described. Methods: The essential oil (EO) was obtained from the leaves of Zanthoxylum monogynum by hydro-distillation and was analyzed by gas chromatograph and gas chromatograph/mass spectrometry (GC and GC/MS). Also the EO of Z. monogynum was evaluated for in vitro cytotoxic activity against six tumor cell lines and for antimicrobial activity, performing disk diffusion and MIC assays with yeast and bacterial strains. Results: The chemical analysis afforded the identification of 18 components (99.0% of the EO). The major components were found to be citronellol (43.0%) and farnesol (32.0%). The in vitro cytotoxic activity against tumor cell lines, resulted in IC50 values ranging from 11-65 µg/mL against all tested cell lines. Antimicrobial activity of the essential oil was also tested and oil was effective, especially against Cryptococcus sp. yeast. All the tested yeast strains showed at least 90% growth inhibition. Conclusions: the essential oil from leaves of Z. monogynum has a different qualitative and quantitative composition when compared to the composition previously described. Also this EO has significant cytotoxic activity and moderate activity against Cryptococcus sp. and Saccharomyces cereviseae yeasts.
Bastos,
Evaluation of the trypanocidal activity of lignans isolated from the leaves of Zanthoxylum naranjillo.
1999, Pubmed
Bastos,
Evaluation of the trypanocidal activity of lignans isolated from the leaves of Zanthoxylum naranjillo.
1999,
Pubmed
Bayala,
Anticancer activity of essential oils and their chemical components - a review.
2014,
Pubmed
Bou,
Chemical composition and cytotoxicity evaluation of essential oil from leaves of Casearia sylvestris, its main compound α-zingiberene and derivatives.
2013,
Pubmed
,
Echinobase
Cao,
Isolation of anti-tumor compounds from the stem bark of Zanthoxylum ailanthoides Sieb. & Zucc. by silica gel column and counter-current chromatography.
2013,
Pubmed
Guleria,
Antioxidant and antimicrobial properties of the essential oil and extracts of Zanthoxylum alatum grown in north-western Himalaya.
2013,
Pubmed
Hammer,
Antimicrobial activity of essential oils and other plant extracts.
1999,
Pubmed
Li,
Zanthoxylum bungeanum essential oil induces apoptosis of HaCaT human keratinocytes.
2016,
Pubmed
Lima,
Anti-inflammatory and analgesic activities of the ethanolic extracts from Zanthoxylum riedelianum (Rutaceae) leaves and stem bark.
2007,
Pubmed
Misra,
Antibacterial, cytotoxic activities and chemical composition of fruits of two Cameroonian Zanthoxylum species.
2013,
Pubmed
Mosmann,
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.
1983,
Pubmed
Qi,
In vitro anthelmintic activity of Zanthoxylum simulans essential oil against Haemonchus contortus.
2015,
Pubmed
Santos,
Assessing the Chemical Composition and Antimicrobial Activity of Essential Oils from Brazilian Plants-Eremanthus erythropappus (Asteraceae), Plectrantuns barbatus, and P. amboinicus (Lamiaceae).
2015,
Pubmed
,
Echinobase
Santos,
Cytotoxic and Antimicrobial Constituents from the Essential Oil of Lippia alba (Verbenaceae).
2016,
Pubmed
,
Echinobase
Souza,
Antifungal activity of plant-derived essential oils on Candida tropicalis planktonic and biofilms cells.
2016,
Pubmed
Swamy,
In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia.
2015,
Pubmed
Swamy,
Antimicrobial Properties of Plant Essential Oils against Human Pathogens and Their Mode of Action: An Updated Review.
2016,
Pubmed
Tiwary,
Chemical composition and larvicidal activities of the essential oil of Zanthoxylum armatum DC (Rutaceae) against three mosquito vectors.
2007,
Pubmed
Tsunozaki,
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.
2013,
Pubmed
Wang,
Acridone alkaloids with cytotoxic and antimalarial activities from Zanthoxylum simullans Hance.
2014,
Pubmed
Wang,
Insecticidal Constituents of Essential Oil Derived from Zanthoxylum armatum against Two Stored-Product Insects.
2015,
Pubmed
