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Mar Drugs
2023 Aug 27;219:. doi: 10.3390/md21090470.
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Carotenoids from Starfish Patiria pectinifera: Therapeutic Activity in Models of Inflammatory Diseases.
Popov AM
,
Kozlovskaya EP
,
Klimovich AA
,
Rutckova TA
,
Vakhrushev AI
,
Hushpulian DM
,
Gazaryan IG
,
Makhankov VV
,
Son OM
,
Tekutyeva LA
.
Abstract
The carotenoids mixture (MC) isolated from the starfish Patiria. pectinifera contains more than 50% astaxanthin, 4-6% each zeaxanthine and lutein, and less pharmacologically active components such as free fatty acids and their glycerides. Astaxanthin, the major component of MC, belongs to the xanthophyll class of carotenoids, and is well known for its antioxidant properties. In this work, in vitro and in vivo studies on the biological activity of MC were carried out. The complex was shown to exhibit anti-inflammatory, anti-allergic and cancer-preventive activity, without any toxicity at a dose of 500 mg/kg. MC effectively improves the clinical picture of the disease progressing, as well as normalizing the cytokine profile and the antioxidant defense system in the in vivo animal models of inflammatory diseases, namely: skin carcinogenesis, allergic contact dermatitis (ACD) and systemic inflammation (SI). In the skin carcinogenesis induced by 7,12-dimethylbenzanthracene, the incidence of papillomas was decreased 1.5 times; 1% MC ointment form in allergic contact dermatitis showed an 80% reduced severity of pathomorphological skin manifestations. Obtained results show that MC from starfish P. pectinifera is an effective remedy for the treatment and prevention of inflammatory processes.
agreement No. 075-15-2022-1143 of 07/07/2022 Ministry of Education and Science of the Russian Federation as part of the implementation of support programs for the development of advanced engineering schools, in accordance with Decree of the Government of the Russian Federation of 04/08/2022 No. 619,
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