Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Echinobase
ECB-ART-42715
PLoS One 2013 Jan 01;81:e53087. doi: 10.1371/journal.pone.0053087.
Show Gene links Show Anatomy links

Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis.

Attoub S , Arafat K , Gélaude A , Al Sultan MA , Bracke M , Collin P , Takahashi T , Adrian TE , De Wever O .


???displayArticle.abstract???
A major challenge for oncologists and pharmacologists is to develop less toxic drugs that will improve the survival of lung cancer patients. Frondoside A is a triterpenoid glycoside isolated from the sea cucumber, Cucumaria frondosa and was shown to be a highly safe compound. We investigated the impact of Frondoside A on survival, migration and invasion in vitro, and on tumor growth, metastasis and angiogenesis in vivo alone and in combination with cisplatin. Frondoside A caused concentration-dependent reduction in viability of LNM35, A549, NCI-H460-Luc2, MDA-MB-435, MCF-7, and HepG2 over 24 hours through a caspase 3/7-dependent cell death pathway. The IC50 concentrations (producing half-maximal inhibition) at 24 h were between 1.7 and 2.5 µM of Frondoside A. In addition, Frondoside A induced a time- and concentration-dependent inhibition of cell migration, invasion and angiogenesis in vitro. Frondoside A (0.01 and 1 mg/kg/day i.p. for 25 days) significantly decreased the growth, the angiogenesis and lymph node metastasis of LNM35 tumor xenografts in athymic mice, without obvious toxic side-effects. Frondoside A (0.1-0.5 µM) also significantly prevented basal and bFGF induced angiogenesis in the CAM angiogenesis assay. Moreover, Frondoside A enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin. These findings identify Frondoside A as a promising novel therapeutic agent for lung cancer.

???displayArticle.pubmedLink??? 23308143
???displayArticle.pmcLink??? PMC3540099
???displayArticle.link??? PLoS One


Genes referenced: impact LOC100887844 LOC115919910 LOC590751


???attribute.lit??? ???displayArticles.show???
References [+] :
Al Marzouqi, Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts. 2011, Pubmed, Echinobase