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ECB-ART-40009
Science 2006 Nov 10;3145801:941-52. doi: 10.1126/science.1133609.
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The genome of the sea urchin Strongylocentrotus purpuratus.

Sea Urchin Genome Sequencing Consortium , Sodergren E , Weinstock GM , Davidson EH , Cameron RA , Gibbs RA , Angerer RC , Angerer LM , Arnone MI , Burgess DR , Burke RD , Coffman JA , Dean M , Elphick MR , Ettensohn CA , Foltz KR , Hamdoun A , Hynes RO , Klein WH , Marzluff W , McClay DR , Morris RL , Mushegian A , Rast JP , Smith LC , Thorndyke MC , Vacquier VD , Wessel GM , Wray G , Zhang L , Elsik CG , Ermolaeva O , Hlavina W , Hofmann G , Kitts P , Landrum MJ , Mackey AJ , Maglott D , Panopoulou G , Poustka AJ , Pruitt K , Sapojnikov V , Song X , Souvorov A , Solovyev V , Wei Z , Whittaker CA , Worley K , Durbin KJ , Shen Y , Fedrigo O , Garfield D , Haygood R , Primus A , Satija R , Severson T , Gonzalez-Garay ML , Jackson AR , Milosavljevic A , Tong M , Killian CE , Livingston BT , Wilt FH , Adams N , Bellé R , Carbonneau S , Cheung R , Cormier P , Cosson B , Croce J , Fernandez-Guerra A , Genevière AM , Goel M , Kelkar H , Morales J , Mulner-Lorillon O , Robertson AJ , Goldstone JV , Cole B , Epel D , Gold B , Hahn ME , Howard-Ashby M , Scally M , Stegeman JJ , Allgood EL , Cool J , Judkins KM , McCafferty SS , Musante AM , Obar RA , Rawson AP , Rossetti BJ , Gibbons IR , Hoffman MP , Leone A , Istrail S , Materna SC , Samanta MP , Stolc V , Tongprasit W , Tu Q , Bergeron KF , Brandhorst BP , Whittle J , Berney K , Bottjer DJ , Calestani C , Peterson K , Chow E , Yuan QA , Elhaik E , Graur D , Reese JT , Bosdet I , Heesun S , Marra MA , Schein J , Anderson MK , Brockton V , Buckley KM , Cohen AH , Fugmann SD , Hibino T , Loza-Coll M , Majeske AJ , Messier C , Nair SV , Pancer Z , Terwilliger DP , Agca C , Arboleda E , Chen N , Churcher AM , Hallböök F , Humphrey GW , Idris MM , Kiyama T , Liang S , Mellott D , Mu X , Murray G , Olinski RP , Raible F , Rowe M , Taylor JS , Tessmar-Raible K , Wang D , Wilson KH , Yaguchi S , Gaasterland T , Galindo BE , Gunaratne HJ , Juliano C , Kinukawa M , Moy GW , Neill AT , Nomura M , Raisch M , Reade A , Roux MM , Song JL , Su YH , Townley IK , Voronina E , Wong JL , Amore G , Branno M , Brown ER , Cavalieri V , Duboc V , Duloquin L , Flytzanis C , Gache C , Lapraz F , Lepage T , Locascio A , Martinez P , Matassi G , Matranga V , Range R , Rizzo F , Röttinger E , Beane W , Bradham C , Byrum C , Glenn T , Hussain S , Manning G , Miranda E , Thomason R , Walton K , Wikramanayke A , Wu SY , Xu R , Brown CT , Chen L , Gray RF , Lee PY , Nam J , Oliveri P , Smith J , Muzny D , Bell S , Chacko J , Cree A , Curry S , Davis C , Dinh H , Dugan-Rocha S , Fowler J , Gill R , Hamilton C , Hernandez J , Hines S , Hume J , Jackson L , Jolivet A , Kovar C , Lee S , Lewis L , Miner G , Morgan M , Nazareth LV , Okwuonu G , Parker D , Pu LL , Thorn R , Wright R .


Abstract
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

PubMed ID: 17095691
PMC ID: PMC3159423
Article link: Science
Grant support: [+]

Genes referenced: LOC100887844

References [+] :
Akira, Pathogen recognition and innate immunity. 2006, Pubmed