ECB-ART-32610
Cell Biol Int Rep
1987 Jun 01;116:457-63. doi: 10.1016/0309-1651(87)90079-8.
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Catecholamine secretion and adenylate cyclase activation in sea urchin eggs.
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The role of neurotransmitters in sea-urchin eggs was investigated by studying their effect on adenylate cyclase of the egg membrane. Maximal stimulation of enzyme activity occurs in the presence of dopamine and GTP. 5-hydroxytriptamine, 5-methoxytriptamine and acetylcholine have no effect on activity, despite a decrease in intracellular cAMP level in eggs treated with 5-hydroxytriptamine antagonists as previously reported (Renaud et al., 1983). High-performance liquid chromatography (HPLC) revealed that dopamine is released from the sea-urchin egg into the external medium following fertilization.
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Genes referenced: LOC100887844 LOC586260