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J Food Sci Technol
2020 Jun 01;576:2283-2292. doi: 10.1007/s13197-020-04266-z.
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Characterization and anti-tumor activity of saponin-rich fractions of South Korean sea cucumbers (Apostichopus japonicus).
Dai YL
,
Kim EA
,
Luo HM
,
Jiang YF
,
Oh JY
,
Heo SJ
,
Jeon YJ
.
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In this study, the saponin-rich fractions of five individual (two Red and three Black) sea cucumbers (Apostichopus japonicus) in South Korea were investigated for their antiproliferative effect against HL-60, B16F10, MCF-7, and Hep3B tumor cell lines. The red sea cucumber saponin-rich fraction (SSC) from Jeju Island (JRe) decreased the growth of HL-60 with an IC50 value of 23.55 ± 3.40 μg/mL, which represented the strongest anticancer activity among the extracts. Further, SSC downregulated B-cell lymphoma extra-large (Bcl-xL), while upregulating, to different degrees, Bcl-2-associated X protein (Bax), caspase-9, caspase-3, PARP cleavage, and apoptotic bodies in cancer cells. Evidence for SSC inducing apoptosis via the mitochondria-mediated pathway was found. The contents of SSCs were determined using ultra high-performance liquid chromatography coupled with a quadrupole orbitrap mass spectrometry to comparatively evaluate the regional influence. In West Sea, the total SSC content of A. japonicus was 15.5 mg/g, representing the highest content, while A. japonicus in the South Sea yielded the lowest content at 8 mg/g. The major saponin constituent in SSC was identified as Holotoxin A1, which may the anti-tumor compound in A. japonicus.
Aminin,
Anticancer activity of sea cucumber triterpene glycosides.
2015,
Pubmed
,
Echinobase
Bagheri,
Ethanolic extract of Brucea javanica inhibit proliferation of HCT-116 colon cancer cells via caspase activation.
2018,
Pubmed
Barry,
Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia.
1990,
Pubmed
Baskić,
Analysis of cycloheximide-induced apoptosis in human leukocytes: fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide.
2006,
Pubmed
Bordbar,
High-value components and bioactives from sea cucumbers for functional foods--a review.
2011,
Pubmed
,
Echinobase
Dai,
Comparing eight types of ginsenosides in ginseng of different plant ages and regions using RRLC-Q-TOF MS/MS.
2020,
Pubmed
Dai,
Characterization and screening of anti-tumor activity of fucoidan from acid-processed hijiki (Hizikia fusiforme).
2019,
Pubmed
Fan,
[Studies on the purification of water-soluble holothurian glycosides from Apostichopus japonicus and their tumor suppressing activity].
2009,
Pubmed
,
Echinobase
Fernando,
3β-Hydroxy-Δ5-steroidal congeners from a column fraction of Dendronephthya puetteri attenuate LPS-induced inflammatory responses in RAW 264.7 macrophages and zebrafish embryo model.
2018,
Pubmed
Jänicke,
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis.
1998,
Pubmed
Kim,
Triterpene glycosides from sea cucumbers and their biological activities.
2012,
Pubmed
,
Echinobase
Kovalchuk,
Estrogenic activity of triterpene glycosides in yeast two-hybrid assay.
2006,
Pubmed
,
Echinobase
Li,
Absorption and Transport of Sea Cucumber Saponins from Apostichopus japonicus.
2016,
Pubmed
,
Echinobase
Mooney,
Apoptotic mechanisms in T47D and MCF-7 human breast cancer cells.
2002,
Pubmed
Nguyen,
Frondoside A from sea cucumber and nymphaeols from Okinawa propolis: Natural anti-cancer agents that selectively inhibit PAK1 in vitro.
2017,
Pubmed
,
Echinobase
Nishanthan,
Effects of processing on proximate and fatty acid compositions of six commercial sea cucumber species of Sri Lanka.
2018,
Pubmed
,
Echinobase
Salakou,
Increased Bax/Bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis.
2007,
Pubmed
Shah,
Analytical methods validation: bioavailability, bioequivalence and pharmacokinetic studies. Conference report.
1991,
Pubmed
Soltani,
Putative mechanism for apoptosis-inducing properties of crude saponin isolated from sea cucumber (Holothuria leucospilota) as an antioxidant compound.
2015,
Pubmed
,
Echinobase
Song,
Characterization of Metabolic Pathways and Absorption of Sea Cucumber Saponins, Holothurin A and Echinoside A, in Vitro and in Vivo.
2017,
Pubmed
,
Echinobase
Thornberry,
Caspases: enemies within.
1998,
Pubmed
Van Dyck,
Qualitative and quantitative saponin contents in five sea cucumbers from the Indian ocean.
2010,
Pubmed
,
Echinobase
Wang,
Antifungal nortriterpene and triterpene glycosides from the sea cucumber Apostichopus japonicus Selenka.
2012,
Pubmed
,
Echinobase
Weng,
Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells.
2005,
Pubmed
Yang,
Determination of the triterpene glycosides in sea cucumbers by liquid chromatography with evaporative light scattering and mass spectrometry detection.
2015,
Pubmed
,
Echinobase
Yun,
Holotoxin A₁ Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells.
2018,
Pubmed
,
Echinobase
Zhang,
Effects of heat treatment on the gel properties of the body wall of sea cucumber (Apostichopus japonicus).
2017,
Pubmed
,
Echinobase
