Semin Cell Dev Biol 2006 Apr 01;172:233-43. doi: 10.1016/j.semcdb.2006.02.007.

Thirty years of calcium signals at fertilization.

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It was discovered about 30 years ago that a dramatic increase in intracellular calcium ion concentration ([Ca(2+)](i)) occurs at fertilization and that this increase acts as the pivotal signal for egg activation. Later, the Ca(2+) signal at fertilization turned out to be ubiquitous among animal species. Extensive advance has been brought during these 30 years in research on spatiotemporal aspects and signaling mechanisms of the [Ca(2+)](i) increase, sperm factors that induce the Ca(2+) response, and cell cycle resumption caused by the [Ca(2+)](i) rise. I provide a historical account of these advances in mammals, sea urchins, and a few other models.

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Genes referenced: ago1b LOC100887844 LOC115919910