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ECB-ART-40535
Arch Pharm Res 2007 Nov 01;3011:1387-91. doi: 10.1007/BF02977361.
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Two new triterpene glycosides from the Vietnamese sea cucumber Holothuria scabra.

Dang NH , Thanh NV , Kiem PV , Huong le M , Minh CV , Kim YH .


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Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 microg/mL (for compound 1) and of 1.12 and 0.57 microg/mL (for compound 2), respectively.

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Genes referenced: LOC100887844 LOC100893907 LOC115919910