Exp Cell Res 1986 Sep 01;1661:23-30. doi: 10.1016/0014-4827(86)90505-7.

Tumor promoters and diacylglycerol activate the Na+/H+ antiporter of sea urchin eggs.

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Various tumor promoters (TPA, lyngbyatoxin and aplysiatoxin) and diacylglycerol induced cytoplasmic alkalinization of sea urchin eggs independently of intracellular Ca2+ release. This response stimulated protein synthesis and was blocked by amiloride or a lack of extracellular Na+, procedures which inhibit the Na+/H+ antiporter. These results suggest that the antiporter which is responsible for cytoplasmic alkalinization in sea urchin eggs is activated directly or indirectly by protein kinase C in a Ca2+-independent manner.

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Genes referenced: LOC100887844 LOC586799 pkcl2