ECB-ART-40934
Zhong Yao Cai
2008 Jul 01;317:1001-3.
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[Screening of bioactive constituents from sea cucumber Holothuria nobilis using conidia of Pyricularia oryzae].
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OBJECTIVE: To study the bioactive triterpene glycosides from sea cucumber Holothuria nobilis. METHODS: Guided by Pyricularia oryzae bioassay method, the glycosides compounds were separated by multi-chromatography, and their structures were elucidated by chemical and spectral analysis. RESULTS: Twelve triterpene glycosides were obtained and their structures were identified, including seven novel saponins. All saponins showed activities on P. oryzae, and most of them exhibited cytotoxicity on P388 and A549 significantly. CONCLUSION: Our researches provided valuable leads for pursuing new anticancer drugs, and established a homebase for further development of H. nobilis which is widely distributed in South China Sea.
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Genes referenced: LOC100887844