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Curr Top Dev Biol
2016 Jan 01;117:553-66. doi: 10.1016/bs.ctdb.2015.11.030.
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Germ Line Mechanics--And Unfinished Business.
Wessel GM
.
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Primordial germ cells are usually made early in the development of an organism. These are the mother of all stem cells that are necessary for propagation of the species, yet use highly diverse mechanisms between organisms. How they are specified, and when and where they form, are central to developmental biology. Using diverse organisms to study this development is illuminating for understanding the mechanics these cells use in this essential function and for identifying the breadth of evolutionary changes that have occurred between species. This essay emphasizes how echinoderms may contribute to the patchwork quilt of our understanding of germ line formation during embryogenesis.
Cheung,
Molecular regulation of stem cell quiescence.
2013, Pubmed
Cheung,
Molecular regulation of stem cell quiescence.
2013,
Pubmed
Cohen,
Nobel committee rewards pioneers of development studies in fruitflies.
1995,
Pubmed
Edmondson,
A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.
1989,
Pubmed
Ephrussi,
Induction of germ cell formation by oskar.
1992,
Pubmed
Ephrussi,
Oskar organizes the germ plasm and directs localization of the posterior determinant nanos.
1991,
Pubmed
Ewen-Campen,
The molecular machinery of germ line specification.
2010,
Pubmed
Extavour,
Mechanisms of germ cell specification across the metazoans: epigenesis and preformation.
2003,
Pubmed
Gavis,
Localization of nanos RNA controls embryonic polarity.
1992,
Pubmed
Hayashi,
Germ cell specification in mice.
2007,
Pubmed
Illmensee,
Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the egg.
1974,
Pubmed
Irish,
The Drosophila posterior-group gene nanos functions by repressing hunchback activity.
1989,
Pubmed
Janic,
Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila.
2010,
Pubmed
Johnson,
Primordial germ cells: the first cell lineage or the last cells standing?
2015,
Pubmed
Juliano,
A conserved germline multipotency program.
2010,
Pubmed
,
Echinobase
Juliano,
Developmental biology. Versatile germline genes.
2010,
Pubmed
Lasko,
The product of the Drosophila gene vasa is very similar to eukaryotic initiation factor-4A.
1988,
Pubmed
Lasko,
The DEAD-box helicase Vasa: evidence for a multiplicity of functions in RNA processes and developmental biology.
2013,
Pubmed
,
Echinobase
Lehmann,
Abdominal segmentation, pole cell formation, and embryonic polarity require the localized activity of oskar, a maternal gene in Drosophila.
1986,
Pubmed
Little,
Independent and coordinate trafficking of single Drosophila germ plasm mRNAs.
2015,
Pubmed
Lynch,
The phylogenetic origin of oskar coincided with the origin of maternally provisioned germ plasm and pole cells at the base of the Holometabola.
2011,
Pubmed
Mahowald,
Interspecific transplantation of polar plasm between Drosophila embryos.
1976,
Pubmed
McLaren,
Germ cells and germ cell transplantation.
1998,
Pubmed
Nakamura-Ishizu,
The analysis, roles and regulation of quiescence in hematopoietic stem cells.
2014,
Pubmed
Nüsslein-Volhard,
Mutations affecting segment number and polarity in Drosophila.
1980,
Pubmed
Paksa,
Zebrafish germ cells: motility and guided migration.
2015,
Pubmed
Rabinowitz,
Nanos is required in somatic blast cell lineages in the posterior of a mollusk embryo.
2008,
Pubmed
Rangan,
Regulating gene expression in the Drosophila germ line.
2008,
Pubmed
Reinardy,
Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers.
2015,
Pubmed
,
Echinobase
Roush,
Nobel prizes: fly development work bears prize-winning fruit.
1995,
Pubmed
Ryu,
RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.
2015,
Pubmed
Seydoux,
Pathway to totipotency: lessons from germ cells.
2006,
Pubmed
Slaidina,
Translational control in germline stem cell development.
2014,
Pubmed
Steptoe,
Birth after the reimplantation of a human embryo.
1978,
Pubmed
Strome,
Specifying and protecting germ cell fate.
2015,
Pubmed
Surani,
Human Germline: A New Research Frontier.
2015,
Pubmed
Swartz,
Localization of Vasa mRNA during early cleavage of the snail Ilyanassa.
2008,
Pubmed
Tam,
The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo.
1996,
Pubmed
Tapscott,
MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.
1988,
Pubmed
Voronina,
Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development.
2008,
Pubmed
,
Echinobase
Weil,
mRNA localization in the Drosophila germline.
2014,
Pubmed
Wessel,
The biology of the germ line in echinoderms.
2014,
Pubmed
,
Echinobase
Wessel,
Origin and development of the germ line in sea stars.
2014,
Pubmed
,
Echinobase
Wharton,
RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos.
1991,
Pubmed
Williamson,
Germ cell development in Drosophila.
1996,
Pubmed
Wright,
Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD.
1989,
Pubmed
Yajima,
The DEAD-box RNA helicase Vasa functions in embryonic mitotic progression in the sea urchin.
2011,
Pubmed
,
Echinobase
Yajima,
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells.
2015,
Pubmed
,
Echinobase
Yajima,
Autonomy in specification of primordial germ cells and their passive translocation in the sea urchin.
2012,
Pubmed
,
Echinobase
Yang,
Structure of Drosophila Oskar reveals a novel RNA binding protein.
2015,
Pubmed
