Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Dyn
2008 Jul 01;2377:1851-61. doi: 10.1002/dvdy.21582.
Show Gene links
Show Anatomy links
Polycomb group gene expression in the sea urchin.
Gustafson EA
,
Wessel GM
.
???displayArticle.abstract???
Embryonic development in metazoan animals involves a remarkable degree of both genetic and epigenetic regulation. Polycomb group (PcG) genes are essential for initiation and maintenance of epigenetic developmental regulation. This report identifies homologous PcG genes representing the core components of three known Polycomb repressive complexes in the sea urchin Strongylocentrotus purpuratus. Quantitative, temporal, and spatial analyses revealed two significant aspects of their transcript expression during embryonic development. First, almost all showed a localized expression pattern in mesenchyme blastula and gastrula-stage embryos. As the embryo specifies its three germ layers, it may require its PcG gene transcripts to remain in localized stem cell populations, but turn-over in differentiating tissues. Second, their transcript levels gradually decreased during larval pluteus stages. This finding is consistent with progressive cell differentiation in the embryo. Taken together, these results suggest that PcG genes are conserved in S. purpuratus and are actively expressed during early embryogenesis.
Angerer,
Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos.
1989, Pubmed,
Echinobase
Angerer,
Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos.
1989,
Pubmed
,
Echinobase
Arenas-Mena,
Expression of the Hox gene complex in the indirect development of a sea urchin.
1998,
Pubmed
,
Echinobase
Arenas-Mena,
Spatial expression of Hox cluster genes in the ontogeny of a sea urchin.
2000,
Pubmed
,
Echinobase
Arnone,
Genetic organization and embryonic expression of the ParaHox genes in the sea urchin S. purpuratus: insights into the relationship between clustering and colinearity.
2006,
Pubmed
,
Echinobase
Atchison,
Transcription factor YY1 functions as a PcG protein in vivo.
2003,
Pubmed
Boyer,
Polycomb complexes repress developmental regulators in murine embryonic stem cells.
2006,
Pubmed
Brown,
The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.
1998,
Pubmed
Bruskin,
Accumulation in embryogenesis of five mRNAs enriched in the ectoderm of the sea urchin pluteus.
1981,
Pubmed
,
Echinobase
Cao,
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
2004,
Pubmed
Cao,
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
2005,
Pubmed
Duncan,
Polycomblike: a gene that appears to be required for the normal expression of the bithorax and antennapedia gene complexes of Drosophila melanogaster.
1982,
Pubmed
Faust,
The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo.
1998,
Pubmed
Finn,
Pfam: clans, web tools and services.
2006,
Pubmed
Fischle,
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
2003,
Pubmed
Francis,
Reconstitution of a functional core polycomb repressive complex.
2001,
Pubmed
Juliano,
Germ line determinants are not localized early in sea urchin development, but do accumulate in the small micromere lineage.
2006,
Pubmed
,
Echinobase
Kamminga,
Cellular memory and hematopoietic stem cell aging.
2006,
Pubmed
Klymenko,
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.
2006,
Pubmed
Kuzmichev,
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation.
2005,
Pubmed
Lee,
Control of developmental regulators by Polycomb in human embryonic stem cells.
2006,
Pubmed
Levine,
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.
2002,
Pubmed
Lewis,
A gene complex controlling segmentation in Drosophila.
1978,
Pubmed
Mohd-Sarip,
Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression.
2002,
Pubmed
Molofsky,
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.
2003,
Pubmed
Müller,
Polycomb response elements and targeting of Polycomb group proteins in Drosophila.
2006,
Pubmed
Pasini,
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
2004,
Pubmed
Qian,
A retinoblastoma-binding protein related to a negative regulator of Ras in yeast.
1993,
Pubmed
Rajasekhar,
Concise review: roles of polycomb group proteins in development and disease: a stem cell perspective.
2007,
Pubmed
Schuettengruber,
Genome regulation by polycomb and trithorax proteins.
2007,
Pubmed
Silva,
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes.
2003,
Pubmed
Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Springer,
Sequence relationships, conserved domains, and expression patterns for maize homologs of the polycomb group genes E(z), esc, and E(Pc).
2002,
Pubmed
Struhl,
A gene product required for correct initiation of segmental determination in Drosophila.
1981,
Pubmed
Strutt,
Co-localization of Polycomb protein and GAGA factor on regulatory elements responsible for the maintenance of homeotic gene expression.
1997,
Pubmed
Trojer,
L3MBTL1, a histone-methylation-dependent chromatin lock.
2007,
Pubmed
Ura,
STAT3 and Oct-3/4 control histone modification through induction of Eed in embryonic stem cells.
2008,
Pubmed
Voronina,
Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development.
2008,
Pubmed
,
Echinobase
Yang,
Noncoding RNAs and intranuclear positioning in monoallelic gene expression.
2007,
Pubmed
Zencak,
Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.
2005,
Pubmed
de la Cruz,
Developmental regulation of Suz 12 localization.
2005,
Pubmed
