ECB-ART-35960
Biochem Biophys Res Commun
1994 Aug 30;2031:674-80. doi: 10.1006/bbrc.1994.2235.
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Reinitiation of meiosis in starfish oocytes requires an increase in nuclear Ca2+.
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Here we report that an increase in nuclear Ca2+ is hormonally regulated and is required for reinitiation of meiosis in starfish oocytes. We have shown in Asterina pectinifera that a Ca2+ transient and a baseline increase of Ca2+ occur both in the cytoplasm and in the nucleus. These increases are in response to 1-methyladenine (1-MA), the hormone responsible for the induction of meiotic maturation. The Ca2+ transients are not necessary for the reinitiation of meiosis. However, blocking the baseline increase in nuclear Ca2+ blocks both the nuclear envelope breakdown (NEBD) and the continuation of meiosis.
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