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ECB-ART-30314
Nature 1979 Nov 01;2825734:89-90. doi: 10.1038/282089a0.
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Membrane response to 1-methyladenine requires the presence of the nucleus.

Dale B , de Santis A , Hoshi M .


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Meiosis is re-initiated in starfish oocytes by the action of the hormone 1-methyladenine (1-MA). It is thought that the primary trigger is localised at the plasma membrane, and early changes reported are the activation of a Na+ pump and variation in membrane potential and conductance. We report here that external application of 1-MA results in an irreversible switching of the starfish oocyte membrane from one stable electrical state to another. This induced change requires the presence of the germinal vesicle.

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