Environ Toxicol Pharmacol 2010 Sep 01;302:181-7. doi: 10.1016/j.etap.2010.06.001.

The neurotoxic effects of monocrotophos on the formation of the serotonergic nervous system and swimming activity in the larvae of the sea urchin Hemicentrotus pulcherrimus.

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The neurotoxicity of monocrotophos (MCP) in the development of the serotonergic nervous system and swimming activity of larvae of the sea urchin, Hemicentrotus pulcherrimus, was examined. Lethal dose 50% of MCP was 43μg/ml. Overall morphology was not affected in larvae that received up to 30μg/ml of MCP soon after fertilization until the 53h post-fertilization pluteus stage. However, while 70±0.6% of larvae in 5μg/ml MCP swam actively, the proportion decreased to 30±1.7% in 30μg/ml MCP. Accordingly, immunoblotting indicated that MCP decreased the relative intensity of immunoreaction of serotonin receptor protein. Whole-mount immunohistochemistry indicated that MCP inhibited serotonergic axon growth, reduced the number of serotonergic cells at the apical ganglion, and perturbed formation of the serotonin receptor cell network. The present study demonstrated that sea urchin larva is a useful model for evaluating the working mechanism of environmental toxicants in neurogenesis and behavior.

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Genes referenced: LOC100887844 LOC100888622 LOC115919910