Lu Y et al. (2018), Cytotoxic Polyhydroxysteroidal Glycosides from ...

ECB-ART-46181

Mar Drugs 2018 Mar 13;163:. doi: 10.3390/md16030092.

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Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae.

Lu Y , Li H , Wang M , Liu Y , Feng Y , Liu K , Tang H .

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Four new polyhydroxysteroidal glycosides-culcinosides A-D (1, 2, 4, and 7)-along with three known compounds-echinasteroside C (3), linckoside F (5), and linckoside L3 (6)-were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated.

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Genes referenced: LOC100887844 LOC100893907 LOC115919910

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References [+] :

Alley, Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. 1988, Pubmed

	Figure 1. The structures of compounds 1–7 isolated from starfish Culcita novaeguineae.
	Figure 2. The key 1H-1H COSY and HMBC correlations of the new compounds culcinosides A–D (1, 2, 4, and 7).
	Figure 3. The key NOESY correlations of the new compounds culcinosides A-D (1, 2, 4, and 7).