Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Proc Natl Acad Sci U S A
2007 Dec 04;10449:19404-9. doi: 10.1073/pnas.0709994104.
Show Gene links
Show Anatomy links
Evolutionary plasticity of developmental gene regulatory network architecture.
Hinman VF
,
Davidson EH
.
???displayArticle.abstract???
Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for embryogenesis in these animals, we discovered an almost perfectly conserved five-gene network subcircuit required for endoderm specification. We show here that the GRN structure upstream and downstream of the conserved network kernel has, by contrast, diverged extensively. Mesoderm specification is accomplished quite differently; the Delta-Notch signaling system is used in radically distinct ways; and various regulatory genes have been coopted to different functions. The conservation of the conserved kernel is thus the more remarkable. The results indicate types of network linkage subject to evolutionary change. An emergent theme is that subcircuit design may be preserved even while the identity of genes performing given roles changes because of alteration in their cis-regulatory control systems.
Britten,
Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty.
1971, Pubmed
Britten,
Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty.
1971,
Pubmed
Calestani,
Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening.
2003,
Pubmed
,
Echinobase
Croce,
ske-T, a T-box gene expressed in the skeletogenic mesenchyme lineage of the sea urchin embryo.
2001,
Pubmed
,
Echinobase
Davidson,
Gene regulatory networks and the evolution of animal body plans.
2006,
Pubmed
Hinman,
Expression and function of a starfish Otx ortholog, AmOtx: a conserved role for Otx proteins in endoderm development that predates divergence of the eleutherozoa.
2003,
Pubmed
,
Echinobase
Hinman,
Developmental gene regulatory network architecture across 500 million years of echinoderm evolution.
2003,
Pubmed
,
Echinobase
Hinman,
Retinoic acid perturbs Otx gene expression in the ascidian pharynx.
2000,
Pubmed
Hinman,
Caught in the evolutionary act: precise cis-regulatory basis of difference in the organization of gene networks of sea stars and sea urchins.
2007,
Pubmed
,
Echinobase
Lee,
Exclusive developmental functions of gatae cis-regulatory modules in the Strongylocentrorus purpuratus embryo.
2007,
Pubmed
,
Echinobase
Lee,
Expression of Spgatae, the Strongylocentrotus purpuratus ortholog of vertebrate GATA4/5/6 factors.
2004,
Pubmed
,
Echinobase
Maruyama,
A Sea Cucumber Homolog of the Mouse T-Brain-1 is Expressed in the Invaginated Cells of the Early Gastrula in Holothuria leucospilota.
2000,
Pubmed
,
Echinobase
Oliveri,
Development. Built to run, not fail.
2007,
Pubmed
Oliveri,
Gene regulatory network controlling embryonic specification in the sea urchin.
2004,
Pubmed
,
Echinobase
Oliveri,
Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.
2006,
Pubmed
,
Echinobase
Oliveri,
A regulatory gene network that directs micromere specification in the sea urchin embryo.
2002,
Pubmed
,
Echinobase
Ransick,
New early zygotic regulators expressed in endomesoderm of sea urchin embryos discovered by differential array hybridization.
2002,
Pubmed
,
Echinobase
Ransick,
cis-regulatory processing of Notch signaling input to the sea urchin glial cells missing gene during mesoderm specification.
2006,
Pubmed
,
Echinobase
Revilla-i-Domingo,
A missing link in the sea urchin embryo gene regulatory network: hesC and the double-negative specification of micromeres.
2007,
Pubmed
,
Echinobase
Revilla-i-Domingo,
R11: a cis-regulatory node of the sea urchin embryo gene network that controls early expression of SpDelta in micromeres.
2004,
Pubmed
,
Echinobase
Rizzo,
Identification and developmental expression of the ets gene family in the sea urchin (Strongylocentrotus purpuratus).
2006,
Pubmed
,
Echinobase
Satoh,
Amphi-Eomes/Tbr1: an amphioxus cognate of vertebrate Eomesodermin and T-Brain1 genes whose expression reveals evolutionarily distinct domain in amphioxus development.
2002,
Pubmed
Sherwood,
LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.
1999,
Pubmed
,
Echinobase
Sodergren,
The genome of the sea urchin Strongylocentrotus purpuratus.
2006,
Pubmed
,
Echinobase
Sweet,
LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties.
2002,
Pubmed
,
Echinobase
Tagawa,
T-Brain expression in the apical organ of hemichordate tornaria larvae suggests its evolutionary link to the vertebrate forebrain.
2000,
Pubmed
Wada,
Phylogenetic relationships among extant classes of echinoderms, as inferred from sequences of 18S rDNA, coincide with relationships deduced from the fossil record.
1994,
Pubmed
,
Echinobase
Walton,
Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.
2006,
Pubmed
,
Echinobase
Yuh,
An otx cis-regulatory module: a key node in the sea urchin endomesoderm gene regulatory network.
2004,
Pubmed
,
Echinobase
Yuh,
Brn1/2/4, the predicted midgut regulator of the endo16 gene of the sea urchin embryo.
2005,
Pubmed
,
Echinobase