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Echinobase
ECB-ART-31467
Dev Biol 1991 Feb 01;1432:389-97. doi: 10.1016/0012-1606(91)90089-l.
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Primary mesenchyme cell migration requires a chondroitin sulfate/dermatan sulfate proteoglycan.

Lane MC , Solursh M .


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Primary mesenchyme cell migration in the sea urchin embryo is inhibited by sulfate deprivation and exposure to exogenous beta-D-xylosides, two treatments known to disrupt proteoglycan synthesis. We show that in the developing sea urchin, exogenous xyloside affects the synthesis by the primary mesenchyme cells of a very large, cell surface chondroitin sulfate/dermatan sulfate proteoglycan. This proteoglycan is present in a partially purified fraction that restores migratory ability to defective cells in vitro. The integrity of this chondroitin sulfate/dermatan sulfate proteoglycan appears essential for primary mesenchyme cell migration since treatment of actively migrating cells with chondroitinase ABC reversibly inhibited their migration in vitro.

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Genes referenced: abcb6 LOC100887844 LOC115919910 LOC115925415 LOC579130