Goldstone JV .

R01 ES015912 NIEHS NIH HHS , R01 ES015912-02 NIEHS NIH HHS , R01-ES015912 NIEHS NIH HHS

Allikmets, A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. 1998, Pubmed

Allikmets, A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance. 1998, Pubmed
Alutoin, Effects of the multiple stressors copper and reduced salinity on the metabolism of the hermatypic coral Porites lutea. 2001, Pubmed
Amiard, Metallothioneins in aquatic invertebrates: their role in metal detoxification and their use as biomarkers. 2006, Pubmed
Amoutzias, One billion years of bZIP transcription factor evolution: conservation and change in dimerization and DNA-binding site specificity. 2007, Pubmed
Annilo, Evolution of the vertebrate ABC gene family: analysis of gene birth and death. 2006, Pubmed
Arkhipchuk, Use of hydra for chronic toxicity assessment of waters intended for human consumption. 2006, Pubmed
Baruch, UV incites diverse levels of DNA breaks in different cellular compartments of a branching coral species. 2005, Pubmed
Berthet, Metallothionein concentration in sponges (Spongia officinalis) as a biomarker of metal contamination. 2005, Pubmed
Blank, Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? 2008, Pubmed
Blomquist, 17Beta-hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae. 2006, Pubmed
Bock, Coordinate regulation of drug metabolism by xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters. 2004, Pubmed
Bouzaiene, Immunohistochemical localization of a retinoic acid-like receptor in nerve cells of two colonial anthozoans (Cnidaria). 2007, Pubmed
Bresell, Bioinformatic and enzymatic characterization of the MAPEG superfamily. 2005, Pubmed
Carbery, Contamination of Caribbean coastal waters by the antifouling herbicide Irgarol 1051. 2006, Pubmed
Cashman, Some distinctions between flavin-containing and cytochrome P450 monooxygenases. 2005, Pubmed
Castro, The genomic environment around the Aromatase gene: evolutionary insights. 2005, Pubmed
Choresh, The mitochondrial 60-kDa heat shock protein in marine invertebrates: biochemical purification and molecular characterization. 2004, Pubmed
Choresh, The 60-kDa heat shock protein (HSP60) of the sea anemone Anemonia viridis: a potential early warning system for environmental changes. 2001, Pubmed
Clemens, Evolution and function of phytochelatin synthases. 2006, Pubmed
Clemens, Caenorhabditis elegans expresses a functional phytochelatin synthase. 2001, Pubmed
Cobbett, Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis. 2002, Pubmed
Darling, Rising starlet: the starlet sea anemone, Nematostella vectensis. 2005, Pubmed
Davidson, Gene regulatory networks and the evolution of animal body plans. 2006, Pubmed
Davies, The Hydra attenuata assay. 1995, Pubmed
Dean, The human ATP-binding cassette (ABC) transporter superfamily. 2001, Pubmed
Dean, Tumour stem cells and drug resistance. 2005, Pubmed
Dean, Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. 2005, Pubmed
Deeley, Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. 2006, Pubmed
Downs, Preliminary examination of short-term cellular toxicological responses of the coral Madracis mirabilis to acute Irgarol 1051 exposure. 2007, Pubmed
Downs, Oxidative stress and seasonal coral bleaching. 2002, Pubmed
Dunn, Broad phylogenomic sampling improves resolution of the animal tree of life. 2008, Pubmed
Eddy, Profile hidden Markov models. 1998, Pubmed
Edgar, MUSCLE: multiple sequence alignment with high accuracy and high throughput. 2004, Pubmed
Epel, Protection of DNA during early development: adaptations and evolutionary consequences. 2003, Pubmed , Echinobase
Eraly, Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. 2004, Pubmed
Ferrier-Pagès, Effects of temperature and UV radiation increases on the photosynthetic efficiency in four scleractinian coral species. 2007, Pubmed
Finkel, Oxidants, oxidative stress and the biology of ageing. 2000, Pubmed
Finnerty, Origins of bilateral symmetry: Hox and dpp expression in a sea anemone. 2004, Pubmed
Finnerty, Ancient origins of axial patterning genes: Hox genes and ParaHox genes in the Cnidaria. 1999, Pubmed
Fritzenwanker, Analysis of forkhead and snail expression reveals epithelial-mesenchymal transitions during embryonic and larval development of Nematostella vectensis. 2004, Pubmed
Fufezan, Singlet oxygen production in herbicide-treated photosystem II. 2002, Pubmed
Fukuhori, Toxic effects of bisphenol A on sexual and asexual reproduction in Hydra oligactis. 2005, Pubmed
Gamage, Human sulfotransferases and their role in chemical metabolism. 2006, Pubmed
Gardinali, Occurrence and transport of Irgarol 1051 and its major metabolite in coastal waters from South Florida. 2004, Pubmed
Ghaskadbi, Ultraviolet irradiation initiates ectopic foot formation in regenerating hydra and promotes budding. 2005, Pubmed
Goldstone, The chemical defensome: environmental sensing and response genes in the Strongylocentrotus purpuratus genome. 2006, Pubmed , Echinobase
Goldstone, Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. 2007, Pubmed , Echinobase
Grasso, The evolution of nuclear receptors: evidence from the coral Acropora. 2001, Pubmed
Guengerich, Analysis of the kinetic mechanism of haloalkane conjugation by mammalian theta-class glutathione transferases. 2003, Pubmed
Hagenbuch, The superfamily of organic anion transporting polypeptides. 2003, Pubmed
Hamdoun, Embryo stability and vulnerability in an always changing world. 2007, Pubmed
Harborne, The functional value of Caribbean coral reef, seagrass and mangrove habitats to ecosystem processes. 2006, Pubmed , Echinobase
Harrington, Synergistic effects of diuron and sedimentation on photosynthesis and survival of crustose coralline algae. 2005, Pubmed
Hayes, Glutathione transferases. 2005, Pubmed
Hecker, On the mechanism of prostacyclin and thromboxane A2 biosynthesis. 1989, Pubmed
Heffernan, Distribution of microsomal CO-binding chromophores and EROD activity in sea anemone tissues. 2000, Pubmed
Heffernan, Spectral analysis and catalytic activities of the microsomal mixed-function oxidase system of the sea anemone (phylum: Cnidaria). 1998, Pubmed
Holdway, The acute and chronic toxicity of cadmium and zinc to two hydra species. 2001, Pubmed
Hyndman, The aldo-keto reductase superfamily homepage. 2003, Pubmed
Igarashi, The heme-Bach1 pathway in the regulation of oxidative stress response and erythroid differentiation. 2006, Pubmed
Jacobsson, Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. 2007, Pubmed
Jakobsson, Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. 1999, Pubmed
Jez, The aldo-keto reductase (AKR) superfamily: an update. 2001, Pubmed
Jin, Aldo-keto reductases and bioactivation/detoxication. 2007, Pubmed
Johnson, In vitro differential developmental toxicity of vitamin A congeners. 1989, Pubmed
Jones, The ecotoxicological effects of Photosystem II herbicides on corals. 2005, Pubmed
Karntanut, A comparison of methods for measuring acute toxicity to Hydra vulgaris. 2000, Pubmed
Karntanut, The toxicity of copper, cadmium and zinc to four different Hydra (Cnidaria: Hydrozoa). 2002, Pubmed
Karntanut, Effects of removing symbiotic green algae on the response of Hydra viridissima (Pallas 1776) to metals. 2005, Pubmed
Kewley, The mammalian basic helix-loop-helix/PAS family of transcriptional regulators. 2004, Pubmed
Kim, Heat-shock proteins: new keys to the development of cytoprotective therapies. 2006, Pubmed
Kimura, Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. 2002, Pubmed
Koljak, The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. 2001, Pubmed
Kostrouch, Retinoic acid X receptor in the diploblast, Tripedalia cystophora. 1998, Pubmed
Kreil, Comparison of sequence masking algorithms and the detection of biased protein sequence regions. 2003, Pubmed
Krueger, Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. 2005, Pubmed
Kusserow, Unexpected complexity of the Wnt gene family in a sea anemone. 2005, Pubmed
Kusuhara, ATP-binding cassette, subfamily G (ABCG family). 2007, Pubmed
Laity, Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). 2007, Pubmed
Lee, Identification of mouse liver aldehyde dehydrogenases that catalyze the oxidation of retinaldehyde to retinoic acid. 1991, Pubmed
Leslie, Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters. 2001, Pubmed
Lesser, Oxidative stress in marine environments: biochemistry and physiological ecology. 2006, Pubmed
Lewis, Substrates of human cytochromes P450 from families CYP1 and CYP2: analysis of enzyme selectivity and metabolism. 2004, Pubmed
Mackenzie, Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. 2005, Pubmed
Magie, Genomic inventory and expression of Sox and Fox genes in the cnidarian Nematostella vectensis. 2005, Pubmed
Matus, Molecular evidence for deep evolutionary roots of bilaterality in animal development. 2006, Pubmed
Merle, Catalase characterization and implication in bleaching of a symbiotic sea anemone. 2007, Pubmed
Miller, The innate immune repertoire in cnidaria--ancestral complexity and stochastic gene loss. 2007, Pubmed
Mitchelmore, Uptake and partitioning of copper and cadmium in the coral Pocillopora damicornis. 2007, Pubmed
Mitchelmore, Development of symbiosis-specific genes as biomarkers for the early detection of cnidarian-algal symbiosis breakdown. 2002, Pubmed
Mitchelmore, Assessing DNA damage in cnidarians using the Comet assay. 2004, Pubmed
Miyake, Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: demonstration of homology to ABC transport genes. 1999, Pubmed
Mizuta, Presence of sex steroids and cytochrome P450 genes in amphioxus. 2007, Pubmed
Morgan, Assessing coral stress responses using molecular biomarkers of gene transcription. 2001, Pubmed
Murphy, Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. 1999, Pubmed
Murphy, The metal-responsive transcription factor-1 contributes to HIF-1 activation during hypoxic stress. 2005, Pubmed
Murphy, Regulation of malignant progression by the hypoxia-sensitive transcription factors HIF-1alpha and MTF-1. 2004, Pubmed
Müller, Retinoids and pattern formation in a hydroid. 1984, Pubmed
Nebert, Analysis of the glutathione S-transferase (GST) gene family. 2004, Pubmed
Negri, Effects of the herbicide diuron on the early life history stages of coral. 2005, Pubmed
Negri, Inhibition of coral fertilisation and larval metamorphosis by tributyltin and copper. 2001, Pubmed
Nelson, Cytochrome P450 nomenclature, 2004. 2006, Pubmed
Nelson, The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. 1993, Pubmed
Nelson, Metazoan cytochrome P450 evolution. 1998, Pubmed
Nemer, Sea urchin metallothionein sequence: key to an evolutionary diversity. 1985, Pubmed , Echinobase
Nguyen, Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. 2003, Pubmed
Osburn, Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. 2008, Pubmed
Pachura-Bouchet, Toxicity of nonylphenol on the cnidarian Hydra attenuata and environmental risk assessment. 2006, Pubmed
Palackal, Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1). 2001, Pubmed
Pascoe, Toxicity of 17alpha-ethinylestradiol and bisphenol A to the freshwater Cnidarian Hydra vulgaris. 2002, Pubmed
Paul, Chemical mediation of interactions among marine organisms. 2004, Pubmed
Paul, Marine chemical ecology. 2006, Pubmed
Penning, Dihydrodiol dehydrogenases and polycyclic aromatic hydrocarbon activation: generation of reactive and redox active o-quinones. 1999, Pubmed
Penning, Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms. 2007, Pubmed
Philp, Cadmium content of the marine sponge Microciona prolifera, other sponges, water and sediment from the eastern Florida panhandle: possible effects on Microciona cell aggregation and potential roles of low pH and low salinity. 1999, Pubmed
Plantivaux, Molecular characterization of two CuZn-superoxide dismutases in a sea anemone. 2004, Pubmed
Ponting, The functional repertoires of metazoan genomes. 2008, Pubmed
Putnam, Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization. 2007, Pubmed
Qi, Antifouling and antibacterial compounds from the gorgonians Subergorgia suberosa and Scripearia gracillis. 2008, Pubmed
Ramos, Induction of mixed-function oxygenase system and antioxidant enzymes in the coral Montastraea faveolata on acute exposure to benzo(a)pyrene. 2007, Pubmed
Reitzel, Genomic survey of candidate stress-response genes in the estuarine anemone Nematostella vectensis. 2008, Pubmed
Richier, Symbiosis-induced adaptation to oxidative stress. 2005, Pubmed
Richier, Characterization of superoxide dismutases in anoxia- and hyperoxia-tolerant symbiotic cnidarians. 2003, Pubmed
Rossi, Competition for space among sessile marine invertebrates: changes in HSP70 expression in two Pacific cnidarians. 2001, Pubmed
Rougée, Alteration of normal cellular profiles in the Scleractinian coral (Pocillopora damicornis) following laboratory exposure to fuel oil. 2006, Pubmed
Runge-Morris, Regulation of sulfotransferases by xenobiotic receptors. 2005, Pubmed
Råberg, Impact of the herbicides 2,4-D and diuron on the metabolism of the coral Porites cylindrica. 2003, Pubmed
Sebens, Recruitment in a sea anemone population: juvenile substrate becomes adult prey. 1981, Pubmed , Echinobase
Shick, Mycosporine-like amino acid content in four species of sea anemones in the genus Anthopleura reflects phylogenetic but not environmental or symbiotic relationships. 2002, Pubmed
Shick, Mycosporine-like amino acids and related Gadusols: biosynthesis, acumulation, and UV-protective functions in aquatic organisms. 2002, Pubmed
Shimada, Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons. 2006, Pubmed
Sica, Secosteroids of marine origin. 2004, Pubmed
Simionato, Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics. 2007, Pubmed
Solé, Components of the cytochrome P450-dependent monooxygenase system and 'NADPH-independent benzo[a]pyrene hydroxylase' activity in a wide range of marine invertebrate species. 2005, Pubmed
Stamatakis, RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. 2006, Pubmed
Starcevic, Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins. 2008, Pubmed
Sullivan, Upgrades to StellaBase facilitate medical and genetic studies on the starlet sea anemone, Nematostella vectensis. 2008, Pubmed
Surh, Bioactivation of benzylic and allylic alcohols via sulfo-conjugation. 1998, Pubmed
Sweet, Organic anion transporter (Slc22a) family members as mediators of toxicity. 2005, Pubmed
Tarrant, Metabolism of estrogens and androgens by scleractinian corals. 2003, Pubmed
Tarrant, Endocrine-like Signaling in Cnidarians: Current Understanding and Implications for Ecophysiology. 2005, Pubmed
Tarrant, Estrone and estradiol-17 beta concentration in tissue of the scleractinian coral, Montipora verrucosa. 1999, Pubmed
Tarrant, Hormonal signaling in cnidarians: do we understand the pathways well enough to know whether they are being disrupted? 2007, Pubmed
Thomas, Rapid birth-death evolution specific to xenobiotic cytochrome P450 genes in vertebrates. 2007, Pubmed
Thornton, Resurrecting the ancestral steroid receptor: ancient origin of estrogen signaling. 2003, Pubmed
Torras, Posterior expression of nanos orthologs during embryonic and larval development of the anthozoan Nematostella vectensis. 2005, Pubmed
Torres, Physiological responses of Acropora cervicornis to increased solar irradiance. 2007, Pubmed
Twan, Sex steroids in scleractinian coral, Euphyllia ancora: implication in mass spawning. 2003, Pubmed
Twan, Hormones and reproduction in scleractinian corals. 2006, Pubmed
Uno, Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. 2001, Pubmed
Vasiliou, Analysis and update of the human aldehyde dehydrogenase (ALDH) gene family. 2005, Pubmed
Vasiliou, Update of the NAD(P)H:quinone oxidoreductase (NQO) gene family. 2006, Pubmed
Whelan, A general empirical model of protein evolution derived from multiple protein families using a maximum-likelihood approach. 2001, Pubmed
Wiens, Induction of heat-shock (stress) protein gene expression by selected natural and anthropogenic disturbances in the octocoral Dendronephthya klunzingeri. 2000, Pubmed
Wiger, In vitro testing for developmental toxicity using the Hydra attenuata assay. 1985, Pubmed
Withers, Sterol patterns of cultured zooxanthellae isolated from marine invertebrates: Synthesis of gorgosterol and 23-desmethylgorgosterol by aposymbiotic algae. 1982, Pubmed
Yakovleva, Differential susceptibility to oxidative stress of two scleractinian corals: antioxidant functioning of mycosporine-glycine. 2004, Pubmed
Yamada, Glycosaminoglycans in Hydra magnipapillata (Hydrozoa, Cnidaria): demonstration of chondroitin in the developing nematocyst, the sting organelle, and structural characterization of glycosaminoglycans. 2007, Pubmed
Ziegler, An overview of the mechanism, substrate specificities, and structure of FMOs. 2002, Pubmed
de Jong, Components of both major axial patterning systems of the Bilateria are differentially expressed along the primary axis of a 'radiate' animal, the anthozoan cnidarian Acropora millepora. 2006, Pubmed