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Mediators Inflamm
2015 Jan 01;2015:419106. doi: 10.1155/2015/419106.
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Ginkgo biloba extract improves insulin signaling and attenuates inflammation in retroperitoneal adipose tissue depot of obese rats.
Hirata BK
,
Banin RM
,
Dornellas AP
,
de Andrade IS
,
Zemdegs JC
,
Caperuto LC
,
Oyama LM
,
Ribeiro EB
,
Telles MM
.
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Due to the high incidence and severity of obesity and its related disorders, it is highly desirable to develop new strategies to treat or even to prevent its development. We have previously described that Ginkgo biloba extract (GbE) improved insulin resistance and reduced body weight gain of obese rats. In the present study we aimed to evaluate the effect of GbE on both inflammatory cascade and insulin signaling in retroperitoneal fat depot of diet-induced obese rats. Rats were fed with high fat diet for 2 months and thereafter treated for 14 days with 500 mg/kg of GbE. Rats were then euthanized and samples from retroperitoneal fat depot were used for western blotting, RT-PCR, and ELISA experiments. The GbE treatment promoted a significant reduction on both food/energy intake and body weight gain in comparison to the nontreated obese rats. In addition, a significant increase of both Adipo R1 and IL-10 gene expressions and IR and Akt phosphorylation was also observed, while NF-κB p65 phosphorylation and TNF-α levels were significantly reduced. Our data suggest that GbE might have potential as a therapy to treat obesity-related metabolic diseases, with special interest to treat obese subjects resistant to adhere to a nutritional education program.
Figure 4. Effect of GbE on Akt phosphorylation levels of retroperitoneal fat depot: insulin-induced Akt phosphorylation levels in retroperitoneal WAT depot of groups: (a) O+V− (n = 8) and O+V+ (n = 9); (b) O+Gb− (n = 8) and O+Gb+ (n = 7) evaluated by western blotting. *
P < 0.05 versus basal levels.
Figure 5. Effect of GbE on inflammatory signaling pathway: total protein levels of TLR4 (O+V n = 6; O+Gb n = 6), MyD88 (O+V n = 13; O+Gb n = 9), NF-κB p65 (O+V n = 5; O+Gb n = 4), and phosphorylation of NF-κB p65 (O+V n = 10; O+Gb n = 8) in retroperitoneal WAT depot evaluated by western blotting. *
P < 0.05 versus O+V.
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