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ECB-ART-52180
Dev Growth Differ 1980 Jan 01;223:495-502. doi: 10.1111/j.1440-169X.1980.00495.x.
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MESENCHYME CELLS IN STARFISH DEVELOPMENT: EFFECT OF TUNICAMYCIN ON THEIR DIFFERENTIATION, MIGRATION AND FUNCTION.

Dan-Sohkawa M , Tamura G , Mitsui H .


Abstract
The effect of tunicamycin, an inhibitor of protein glycosylation, on starfish development was investigated. Specific developmental events such as 1) bulging of the archenteron tip, 2) migration of mesenchyme cells, 3) formation of coelomic pouches and 4) mouth formation, are inhibited in the presence of this drug. These events are discussed in connection with differentiation, migration and function of mesenchyme cells. The possibility is discussed that tunicamycin exerts its effect by interfering with de novo synthesis of a cell surface factor(s) supporting dynamic cell surface activities.

PubMed ID: 37281662
Article link: Dev Growth Differ