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Br J Pharmacol
2004 Aug 01;1428:1203-7. doi: 10.1038/sj.bjp.0705888.
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The NAADP receptor: commentary on Billington et al.
Galione A
,
Parrington J
,
Dowden J
.
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NAADP is a recently described calcium-mobilizing messenger. First discovered as a potent calcium-releasing molecule in sea urchin eggs, its actions have now been reported in several mammalian cell types. In the sea urchin egg, NAADP-sensitive calcium release channels appear distinct from inositol trisphosphate or ryanodine receptors, and are mainly localized to acidic compartments. In this study, Billington et al. extend the pharmacology of the putative NAADP receptor utilizing molecules unrelated to NAADP itself. This work may provide an important step in developing selective NAADP receptor modulators that will help define the role of NAADP in cell signalling.
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996, Pubmed,
Echinobase
Aarhus,
Activation and inactivation of Ca2+ release by NAADP+.
1996,
Pubmed
,
Echinobase
Aarhus,
ADP-ribosyl cyclase and CD38 catalyze the synthesis of a calcium-mobilizing metabolite from NADP.
1995,
Pubmed
Bak,
NAADP receptors are present and functional in the heart.
2001,
Pubmed
Berg,
Nicotinic acid adenine dinucleotide phosphate (NAADP(+)) is an essential regulator of T-lymphocyte Ca(2+)-signaling.
2000,
Pubmed
Berridge,
Solubilization of receptors for the novel Ca2+-mobilizing messenger, nicotinic acid adenine dinucleotide phosphate.
2002,
Pubmed
,
Echinobase
Billington,
Characterization of NAADP(+) binding in sea urchin eggs.
2000,
Pubmed
,
Echinobase
Billington,
Production and characterization of reduced NAADP (nicotinic acid-adenine dinucleotide phosphate).
2004,
Pubmed
,
Echinobase
Boittin,
Nicotinic acid adenine dinucleotide phosphate mediates Ca2+ signals and contraction in arterial smooth muscle via a two-pool mechanism.
2002,
Pubmed
Burdakov,
Two neuropeptides recruit different messenger pathways to evoke Ca2+ signals in the same cell.
2000,
Pubmed
Cancela,
Two different but converging messenger pathways to intracellular Ca(2+) release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate.
2000,
Pubmed
Cancela,
Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers.
2002,
Pubmed
Cancela,
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
1999,
Pubmed
,
Echinobase
Churchill,
NAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggs.
2002,
Pubmed
,
Echinobase
Churchill,
Sperm deliver a new second messenger: NAADP.
2003,
Pubmed
,
Echinobase
Churchill,
Spatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradients.
2000,
Pubmed
,
Echinobase
Clapper,
Pyridine nucleotide metabolites stimulate calcium release from sea urchin egg microsomes desensitized to inositol trisphosphate.
1987,
Pubmed
,
Echinobase
Dickinson,
Modulation of NAADP (nicotinic acid-adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations.
2003,
Pubmed
,
Echinobase
Galione,
Ca(2+)-induced Ca2+ release in sea urchin egg homogenates: modulation by cyclic ADP-ribose.
1991,
Pubmed
,
Echinobase
Galione,
Interactions between calcium release pathways: multiple messengers and multiple stores.
2002,
Pubmed
,
Echinobase
Genazzani,
Unique inactivation properties of NAADP-sensitive Ca2+ release.
1996,
Pubmed
,
Echinobase
Genazzani,
NAADP: an atypical Ca2+-release messenger?
2002,
Pubmed
Genazzani,
Pharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin egg.
1997,
Pubmed
,
Echinobase
Gerasimenko,
NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors.
2003,
Pubmed
Hohenegger,
Nicotinic acid-adenine dinucleotide phosphate activates the skeletal muscle ryanodine receptor.
2002,
Pubmed
Howard,
Formation and hydrolysis of cyclic ADP-ribose catalyzed by lymphocyte antigen CD38.
1993,
Pubmed
Lee,
Functional visualization of the separate but interacting calcium stores sensitive to NAADP and cyclic ADP-ribose.
2000,
Pubmed
,
Echinobase
Lee,
Caged nicotinic acid adenine dinucleotide phosphate. Synthesis and use.
1997,
Pubmed
,
Echinobase
Lee,
Structural determinants of nicotinic acid adenine dinucleotide phosphate important for its calcium-mobilizing activity.
1997,
Pubmed
,
Echinobase
Lee,
Fluorescent analogs of NAADP with calcium mobilizing activity.
1998,
Pubmed
,
Echinobase
Lee,
Calcium signaling: NAADP ascends as a new messenger.
2003,
Pubmed
,
Echinobase
Lee,
A derivative of NADP mobilizes calcium stores insensitive to inositol trisphosphate and cyclic ADP-ribose.
1995,
Pubmed
,
Echinobase
Masgrau,
NAADP: a new second messenger for glucose-induced Ca2+ responses in clonal pancreatic beta cells.
2003,
Pubmed
Mitchell,
Ryanodine receptor type I and nicotinic acid adenine dinucleotide phosphate receptors mediate Ca2+ release from insulin-containing vesicles in living pancreatic beta-cells (MIN6).
2003,
Pubmed
Moccia,
NAADP activates a Ca2+ current that is dependent on F-actin cytoskeleton.
2003,
Pubmed
,
Echinobase
Patel,
Unique kinetics of nicotinic acid-adenine dinucleotide phosphate (NAADP) binding enhance the sensitivity of NAADP receptors for their ligand.
2000,
Pubmed
,
Echinobase
Patel,
Coordination of Ca2+ signalling by NAADP.
2001,
Pubmed
Patel,
NAADP-induced Ca2+ release -- a new signalling pathway.
2004,
Pubmed
Rusinko,
Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity.
1989,
Pubmed
,
Echinobase
Schomer,
Redox changes during fertilization and maturation of marine invertebrate eggs.
1998,
Pubmed
,
Echinobase
Yamasaki,
Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells.
2004,
Pubmed
