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ECB-ART-40929
J Cell Biol 2008 Nov 03;1833:471-83. doi: 10.1083/jcb.200807129.
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An agent-based model contrasts opposite effects of dynamic and stable microtubules on cleavage furrow positioning.

Odell GM , Foe VE .


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From experiments by Foe and von Dassow (Foe, V.E., and G. von Dassow. 2008. J. Cell Biol. 183:457-470) and others, we infer a molecular mechanism for positioning the cleavage furrow during cytokinesis. Computer simulations reveal how this mechanism depends on quantitative motor-behavior details and explore how robustly this mechanism succeeds across a range of cell sizes. The mechanism involves the MKLP1 (kinesin-6) component of centralspindlin binding to and walking along microtubules to stimulate cortical contractility where the centralspindlin complex concentrates. The majority of astral microtubules are dynamically unstable. They bind most MKLP1 and suppress cortical Rho/myosin II activation because the tips of unstable microtubules usually depolymerize before MKLP1s reach the cortex. A subset of astral microtubules stabilizes during anaphase, becoming effective rails along which MKLP1 can actually reach the cortex. Because stabilized microtubules aim statistically at the equatorial spindle midplane, that is where centralspindlin accumulates to stimulate furrow formation.

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Genes referenced: cep152 dnah3 LOC100893746 LOC100893907 LOC115919910 LOC115925415 LOC590297 tubgcp2


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References [+] :
Adams, pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis. 1998, Pubmed