ECB-ART-44247
J Immunol Res
2015 Jan 01;2015:832057. doi: 10.1155/2015/832057.
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Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases.
Campos JH
,
Soares RP
,
Ribeiro K
,
Andrade AC
,
Batista WL
,
Torrecilhas AC
.
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Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases.
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Genes referenced: LOC115919910
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References [+] :
Acevedo,
Bacterial outer membrane vesicles and vaccine applications.
2014, Pubmed
Acevedo, Bacterial outer membrane vesicles and vaccine applications. 2014, Pubmed
Aghasadeghi, Application of outer membrane vesicle of Neisseria meningitidis serogroup B as a new adjuvant to induce strongly Th1-oriented responses against HIV-1. 2011, Pubmed
Al-Nedawi, Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. 2008, Pubmed
Albacker, Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. 2013, Pubmed
Albuquerque, A Paracoccidioides brasiliensis glycan shares serologic and functional properties with cryptococcal glucuronoxylomannan. 2012, Pubmed
Albuquerque, Vesicular transport in Histoplasma capsulatum: an effective mechanism for trans-cell wall transfer of proteins and lipids in ascomycetes. 2008, Pubmed
Aline, Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection. 2004, Pubmed
Almeida, Highly purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents. 2000, Pubmed
Almeida, Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analyses. 2001, Pubmed
Almeida, Lytic anti-alpha-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi. 1994, Pubmed
Altindis, Proteomic analysis of Vibrio cholerae outer membrane vesicles. 2014, Pubmed
Andreu, Tetraspanins in extracellular vesicle formation and function. 2014, Pubmed
Atay, Oncogenic KIT-containing exosomes increase gastrointestinal stromal tumor cell invasion. 2014, Pubmed
Baker, Microbial biosynthesis of designer outer membrane vesicles. 2014, Pubmed
Bartha, Adaptation on a genomic scale. 2015, Pubmed
Bartolini, Recombinant outer membrane vesicles carrying Chlamydia muridarum HtrA induce antibodies that neutralize chlamydial infection in vitro. 2013, Pubmed
Bauman, Purification of outer membrane vesicles from Pseudomonas aeruginosa and their activation of an IL-8 response. 2006, Pubmed
Bauman, Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells. 2009, Pubmed
Bayer-Santos, Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins. 2013, Pubmed
Beauvillain, Exosomes are an effective vaccine against congenital toxoplasmosis in mice. 2009, Pubmed
Beauvillain, A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice. 2007, Pubmed
Bernal, Surface analysis of Dicrocoelium dendriticum. The molecular characterization of exosomes reveals the presence of miRNAs. 2014, Pubmed
Beveridge, Structures of gram-negative cell walls and their derived membrane vesicles. 1999, Pubmed
Bhatnagar, Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. 2007, Pubmed
Bjune, Effect of outer membrane vesicle vaccine against group B meningococcal disease in Norway. 1991, Pubmed
Bottero, Outer membrane vesicles derived from Bordetella parapertussis as an acellular vaccine against Bordetella parapertussis and Bordetella pertussis infection. 2013, Pubmed
Bourguin, Murine dendritic cells pulsed in vitro with Toxoplasma gondii antigens induce protective immunity in vivo. 1998, Pubmed
Campos, Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. 2001, Pubmed
Campos, Augmented plasma microparticles during acute Plasmodium vivax infection. 2010, Pubmed
Caron, From tailor-made to ready-to-wear meningococcal B vaccines: longitudinal study of a clonal meningococcal B outbreak. 2011, Pubmed
Casadevall, Vesicular transport across the fungal cell wall. 2009, Pubmed
Cestari, Trypanosoma cruzi immune evasion mediated by host cell-derived microvesicles. 2012, Pubmed
Chen, Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine. 2011, Pubmed
Chen, Exosomes from docetaxel-resistant breast cancer cells alter chemosensitivity by delivering microRNAs. 2014, Pubmed
Chen, 786-0 Renal cancer cell line-derived exosomes promote 786-0 cell migration and invasion in vitro. 2014, Pubmed
Choi, Proteomic characterization of the outer membrane vesicle of Pseudomonas putida KT2440. 2014, Pubmed
Colombo, Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. 2014, Pubmed
Corcoran, miR-34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression. 2014, Pubmed
Coura, Chagas disease: control, elimination and eradication. Is it possible? 2013, Pubmed
Cronemberger-Andrade, Extracellular vesicles from Leishmania-infected macrophages confer an anti-infection cytokine-production profile to naïve macrophages. 2014, Pubmed
Deatherage, Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. 2012, Pubmed
Deknuydt, Diversion of the host humoral response: a novel virulence mechanism of Haemophilus influenzae mediated via outer membrane vesicles. 2014, Pubmed
Del Cacho, Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes. 2011, Pubmed
Delbos, Impact of MenBvac, an outer membrane vesicle (OMV) vaccine, on the meningococcal carriage. 2013, Pubmed
Dorward, DNA Is Packaged within Membrane-Derived Vesicles of Gram-Negative but Not Gram-Positive Bacteria. 1990, Pubmed
Dutta, Interactions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells. 2014, Pubmed
Eisenman, Vesicle-associated melanization in Cryptococcus neoformans. 2009, Pubmed
Ferguson, The structure, biosynthesis and functions of glycosylphosphatidylinositol anchors, and the contributions of trypanosome research. 1999, Pubmed
Fiocca, Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium. 1999, Pubmed
Fischer von Mollard, rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. 1990, Pubmed
Fonseca, Immunomodulatory effects of serotype B glucuronoxylomannan from Cryptococcus gattii correlate with polysaccharide diameter. 2010, Pubmed
Free, Fungal cell wall organization and biosynthesis. 2013, Pubmed
Freixeiro, Study of the stability of proteoliposomes as vehicles for vaccines against Neisseria meningitidis based on recombinant porin complexes. 2013, Pubmed
Garcia-Rivera, Comparative analysis of Cryptococcus neoformans acid-resistant particles generated from pigmented cells grown in different laccase substrates. 2005, Pubmed
Geiger, Exocytosis and protein secretion in Trypanosoma. 2010, Pubmed
Germain, Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles. 2007, Pubmed
Golgher, Innate and acquired immunity in the pathogenesis of Chagas disease. 2004, Pubmed
Gonçalves, Trypanosoma cruzi: shedding of surface antigens as membrane vesicles. 1991, Pubmed
Guimarães, Structural diversity and biological significance of glycosphingolipids in pathogenic and opportunistic fungi. 2014, Pubmed
Higginbotham, Amphiregulin exosomes increase cancer cell invasion. 2011, Pubmed
Holst, Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): lessons from past programs and implications for the future. 2013, Pubmed
Hsu, Exosomes as a tumor vaccine: enhancing potency through direct loading of antigenic peptides. 2003, Pubmed
Hunter, Modulation of innate immunity by Toxoplasma gondii virulence effectors. 2012, Pubmed
Jiang, LncRNA: a new player in 1α, 25(OH)(2) vitamin D(3) /VDR protection against skin cancer formation. 2014, Pubmed
Kadurugamuwa, Virulence factors are released from Pseudomonas aeruginosa in association with membrane vesicles during normal growth and exposure to gentamicin: a novel mechanism of enzyme secretion. 1995, Pubmed
Kahlert, Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. 2014, Pubmed
Kesty, Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 2004, Pubmed
Kesty, Incorporation of heterologous outer membrane and periplasmic proteins into Escherichia coli outer membrane vesicles. 2004, Pubmed
Kim, Immunization with Escherichia coli outer membrane vesicles protects bacteria-induced lethality via Th1 and Th17 cell responses. 2013, Pubmed
Kim, Staphylococcus aureus-derived extracellular vesicles induce neutrophilic pulmonary inflammation via both Th1 and Th17 cell responses. 2012, Pubmed
Kim, Structural modifications of outer membrane vesicles to refine them as vaccine delivery vehicles. 2009, Pubmed
Kouokam, Active cytotoxic necrotizing factor 1 associated with outer membrane vesicles from uropathogenic Escherichia coli. 2006, Pubmed
Kourembanas, Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. 2015, Pubmed
Kuehn, Bacterial outer membrane vesicles and the host-pathogen interaction. 2005, Pubmed
Kulkarni, Biogenesis and multifaceted roles of outer membrane vesicles from Gram-negative bacteria. 2014, Pubmed
Kulp, Biological functions and biogenesis of secreted bacterial outer membrane vesicles. 2010, Pubmed
Lambertz, Secreted virulence factors and immune evasion in visceral leishmaniasis. 2012, Pubmed
Le Pecq, Dexosomes as a therapeutic cancer vaccine: from bench to bedside. 2005, Pubmed
Lee, Proteomics in gram-negative bacterial outer membrane vesicles. 2008, Pubmed
Lee, Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. 2009, Pubmed
Li, Exosomes derived from Rab27a‑overexpressing tumor cells elicit efficient induction of antitumor immunity. 2013, Pubmed
Liu, Increased exosomal microRNA-21 and microRNA-146a levels in the cervicovaginal lavage specimens of patients with cervical cancer. 2014, Pubmed
Liu, Functional prostate-specific membrane antigen is enriched in exosomes from prostate cancer cells. 2014, Pubmed
Magdesian, Infection by Trypanosoma cruzi. Identification of a parasite ligand and its host cell receptor. 2001, Pubmed
Mahmoodzadeh Hosseini, Exosome/staphylococcal enterotoxin B, an anti tumor compound against pancreatic cancer. 2014, Pubmed
Mahmoodzadeh Hosseini, Staphylococcal entorotoxin B anchored exosome induces apoptosis in negative esterogen receptor breast cancer cells. 2014, Pubmed
Manning, Functional advantages conferred by extracellular prokaryotic membrane vesicles. 2013, Pubmed
Mantel, Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. 2013, Pubmed
Marcilla, Extracellular vesicles in parasitic diseases. 2014, Pubmed
Martin-Jaular, Exosomes from Plasmodium yoelii-infected reticulocytes protect mice from lethal infections. 2011, Pubmed
Martínez-Lorenzo, Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles. 1999, Pubmed
Mashburn-Warren, Gram-negative outer membrane vesicles: beyond the cell surface. 2008, Pubmed
Mathivanan, ExoCarta 2012: database of exosomal proteins, RNA and lipids. 2012, Pubmed
Mathivanan, Exosomes: extracellular organelles important in intercellular communication. 2010, Pubmed
Mayrand, Biological activities of outer membrane vesicles. 1989, Pubmed
Messerli, Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes. 2010, Pubmed
Moshiri, Outer membrane vesicle: a macromolecule with multifunctional activity. 2012, Pubmed
Newman, Iron uptake and virulence in Histoplasma capsulatum. 2013, Pubmed
Nimrichter, Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials. 2011, Pubmed
Noble, Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. 2010, Pubmed
Näslund, Cancer immunotherapy with exosomes requires B-cell activation. 2013, Pubmed
Näslund, Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity. 2013, Pubmed
Ohshima, Exosome-mediated extracellular release of polyadenylate-binding protein 1 in human metastatic duodenal cancer cells. 2014, Pubmed
Oliveira, Characterization of yeast extracellular vesicles: evidence for the participation of different pathways of cellular traffic in vesicle biogenesis. 2010, Pubmed
Oliveira, Extracellular vesicles from Cryptococcus neoformans modulate macrophage functions. 2010, Pubmed
Oliveira, Cryptococcus neoformans cryoultramicrotomy and vesicle fractionation reveals an intimate association between membrane lipids and glucuronoxylomannan. 2009, Pubmed
Quah, The immunogenicity of dendritic cell-derived exosomes. 2005, Pubmed
Ramachandra, Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. 2010, Pubmed
Regev-Rudzki, Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. 2013, Pubmed
Ren, Characterization of extended co-culture of non-typeable Haemophilus influenzae with primary human respiratory tissues. 2012, Pubmed
Riches, Regulation of exosome release from mammary epithelial and breast cancer cells - a new regulatory pathway. 2014, Pubmed
Rittershaus, Glucosylceramide synthase is an essential regulator of pathogenicity of Cryptococcus neoformans. 2006, Pubmed
Rivera, Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins. 2010, Pubmed
Rodrigues, Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence. 2008, Pubmed
Rodrigues, Fungal polysaccharides: biological activity beyond the usual structural properties. 2011, Pubmed
Rodrigues, Vesicular polysaccharide export in Cryptococcus neoformans is a eukaryotic solution to the problem of fungal trans-cell wall transport. 2007, Pubmed
Rodrigues, The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles. 2014, Pubmed
Rodrigues, Human antibodies against a purified glucosylceramide from Cryptococcus neoformans inhibit cell budding and fungal growth. 2000, Pubmed
Rodrigues, Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection. 2007, Pubmed
Rodríguez-Ortega, Characterization and identification of vaccine candidate proteins through analysis of the group A Streptococcus surface proteome. 2006, Pubmed
Rosas, Synthesis of polymerized melanin by Cryptococcus neoformans in infected rodents. 2000, Pubmed
Rossi, Modulation of endotoxicity of Shigella generalized modules for membrane antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants. 2014, Pubmed
Sadarangani, Serogroup B meningococcal vaccines-an unfinished story. 2010, Pubmed
Schnitzer, Fragments of antigen-loaded dendritic cells (DC) and DC-derived exosomes induce protective immunity against Leishmania major. 2010, Pubmed
Sedlik, Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms. 2014, Pubmed
Serna, A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas disease. 2014, Pubmed
Sharpe, Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae. 2011, Pubmed
Shimbo, Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. 2014, Pubmed
Silverman, Leishmania exosomes deliver preemptive strikes to create an environment permissive for early infection. 2011, Pubmed
Silverman, Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes. 2011, Pubmed
Silverman, Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells. 2010, Pubmed
Sjursen, IgG subclass antibodies to serogroup B meningococcal outer membrane antigens following infection and vaccination. 1990, Pubmed
Smyth, Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro. 2014, Pubmed
Soares, Intraspecies variation in Trypanosoma cruzi GPI-mucins: biological activities and differential expression of α-galactosyl residues. 2012, Pubmed
Stegmayr, Promotive effect on human sperm progressive motility by prostasomes. 1982, Pubmed
Taborda, Melanin as a virulence factor of Paracoccidioides brasiliensis and other dimorphic pathogenic fungi: a minireview. 2008, Pubmed
Takahashi, Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer. 2014, Pubmed
Tanimura, Matrix vesicles in atherosclerotic calcification. 1983, Pubmed
Taylor, The origin, function, and diagnostic potential of RNA within extracellular vesicles present in human biological fluids. 2013, Pubmed
Théry, Exosomes: composition, biogenesis and function. 2002, Pubmed
Théry, Membrane vesicles as conveyors of immune responses. 2009, Pubmed
Théry, Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomes. 2002, Pubmed
Toledo, Characterization of monoclonal antibody MEST-2 specific to glucosylceramide of fungi and plants. 2001, Pubmed
Torrecilhas, Vesicles as carriers of virulence factors in parasitic protozoan diseases. 2012, Pubmed , Echinobase
Trocoli Torrecilhas, Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory response. 2009, Pubmed
Twu, Trichomonas vaginalis exosomes deliver cargo to host cells and mediate host∶parasite interactions. 2013, Pubmed
Valencia, miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization. 2014, Pubmed
Vallejo, The pathogenic fungus Paracoccidioides brasiliensis exports extracellular vesicles containing highly immunogenic α-Galactosyl epitopes. 2011, Pubmed
Vallejo, Lipidomic analysis of extracellular vesicles from the pathogenic phase of Paracoccidioides brasiliensis. 2012, Pubmed
Vallejo, Vesicle and vesicle-free extracellular proteome of Paracoccidioides brasiliensis: comparative analysis with other pathogenic fungi. 2012, Pubmed
Vargas, Compositional and immunobiological analyses of extracellular vesicles released by Candida albicans. 2015, Pubmed
Viaud, Updated technology to produce highly immunogenic dendritic cell-derived exosomes of clinical grade: a critical role of interferon-γ. 2011, Pubmed
Wang, Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. 2014, Pubmed
Wang, Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer. 2014, Pubmed
Wang, Cryptococcus neoformans melanin and virulence: mechanism of action. 1995, Pubmed
Wei, Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells. 2014, Pubmed
Wilson, Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors. 2014, Pubmed
Wylie, A systematic review of the efficacy of prophylactic control measures for naturally-occurring canine leishmaniosis, part I: vaccinations. 2014, Pubmed
Xiao, Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin. 2014, Pubmed
Yao, Tumor cell-derived exosome-targeted dendritic cells stimulate stronger CD8+ CTL responses and antitumor immunities. 2013, Pubmed
Yaron, Vesicle-mediated transfer of virulence genes from Escherichia coli O157:H7 to other enteric bacteria. 2000, Pubmed
Zaragoza, The capsule of the fungal pathogen Cryptococcus neoformans. 2009, Pubmed
Zhang, Cell biology. Unconventional secretion, unconventional solutions. 2013, Pubmed
Zhao, Pseudomonas aeruginosa outer membrane vesicles modulate host immune responses by targeting the Toll-like receptor 4 signaling pathway. 2013, Pubmed
Zhou, Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. 2014, Pubmed
da Silva, Melanin in the dimorphic fungal pathogen Paracoccidioides brasiliensis: effects on phagocytosis, intracellular resistance and drug susceptibility. 2006, Pubmed
de Assis, Glycoconjugates in New World species of Leishmania: polymorphisms in lipophosphoglycan and glycoinositolphospholipids and interaction with hosts. 2012, Pubmed
del Cacho, Tetraspanin-3 regulates protective immunity against Eimeria tenella infection following immunization with dendritic cell-derived exosomes. 2013, Pubmed
del Cacho, Induction of protective immunity against Eimeria tenella, Eimeria maxima, and Eimeria acervulina infections using dendritic cell-derived exosomes. 2012, Pubmed
van Duin, Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin. 2002, Pubmed
van der Ley, Next-generation outer membrane vesicle vaccines against Neisseria meningitidis based on nontoxic LPS mutants. 2011, Pubmed
van der Pol, Classification, functions, and clinical relevance of extracellular vesicles. 2012, Pubmed