Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Br J Cancer
1997 Jan 01;753:324-32. doi: 10.1038/bjc.1997.54.
Show Gene links
Show Anatomy links
In vivo anti-tumour effect of 3''-sulphonoquinovosyl 1''-monoacylglyceride isolated from sea urchin (Strongylocentrotus intermedius) intestine.
Sahara H
,
Ishikawa M
,
Takahashi N
,
Ohtani S
,
Sato N
,
Gasa S
,
Akino T
,
Kikuchi K
.
???displayArticle.abstract???
Extracts from sea urchin intestine were screened for new anti-tumour drugs. Four glycolipids, 3''-sulphonoquinovosyl-1'', 2''-diacylglyceride (A-4), 3''-sulphonoquinovosyl-1''-monoacylglyceride (2''-lyso A-4, A-5), NeuGc(alpha)2-6Glc(beta)1-1ceramide (A-6) and HSO3-8NeuGc(alpha)2-6Glc(beta)1-1ceramide (A-7), were isolated from the intestine of sea urchin, Strongylocentrotus intermedius, and characterized by means of proton nuclear magnetic resonance spectroscopy and fast atom bombardment mass spectrometry. When tested for cytotoxic activity against tumour cells in vitro, A-5 showed significant activity, but A-4, -6 and -7 did not. In addition, the hydrophilic derivatives of A-4 or -5 had no cytotoxicity. Furthermore, the anti-tumour effects on nude mice bearing solid tumours of a human lung adenocarcinoma cell line A-549 were evaluated in vivo using A-4 and -5. As a result, A-5 was found to be significantly effective in suppressing the growth of solid tumours, whereas A-4 had no effect. Pathologically, the solid tumours showed haemorrhagic necrosis areas after treatment with A-5. In this study, we have demonstrated the anti-tumour effect of sulphonoquinovosyl-lysoglyceride (A-5), which provides important information that this sulpholipid could be a useful drug for cancer chemotherapy.
Anderson,
The lipid composition of the non-photosynthetic diatom Nitzschia alba.
1978, Pubmed
Anderson,
The lipid composition of the non-photosynthetic diatom Nitzschia alba.
1978,
Pubmed
BENSON,
THE PLANT SULFOLIPID.
1963,
Pubmed
Benson,
A SULFOLIPID IN PLANTS.
1959,
Pubmed
Bishop,
Misguided cells: the genesis of human cancer.
1994,
Pubmed
GOTTFRIED,
THE BIOCHEMISTRY OF PLASMALOGENS. II. HEMOLYTIC ACTIVITY OF SOME PLASMALOGEN DERIVATIVES.
1963,
Pubmed
Hannun,
Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses.
1987,
Pubmed
Hartwell,
Cell cycle control and cancer.
1994,
Pubmed
Isono,
Biochemistry of glycolipids of sea urchin gametes. I. Separation and characterization of new type of sulfolipid and sialoglycolipid.
1966,
Pubmed
,
Echinobase
Isono,
Effect of egg sulpholipid on respiration of sea urchin spermatozoa.
1967,
Pubmed
,
Echinobase
Jennemann,
Glycosphingolipids of human gliomas.
1990,
Pubmed
Koerner,
High-resolution proton NMR studies of gangliosides. 1. Use of homonuclear two-dimensional spin-echo J-correlated spectroscopy for determination of residue composition and anomeric configurations.
1983,
Pubmed
Kriat,
Analysis of plasma lipids by NMR spectroscopy: application to modifications induced by malignant tumors.
1993,
Pubmed
Kubo,
Gangliosides from the eggs of the sea urchin, Anthocidaris crassispina.
1990,
Pubmed
,
Echinobase
Langworthy,
A sulfonolipid and novel glucosamidyl glycolipids from the extreme thermoacidophile Bacillus acidocaldarius.
1976,
Pubmed
Merrill,
Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction.
1989,
Pubmed
Nagai,
Occurrence of animal sulfolipid in the gametes of sea urchins.
1965,
Pubmed
,
Echinobase
Oishi,
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction.
1988,
Pubmed
ROBINSON,
Lysolecithin.
1961,
Pubmed
Rabbitts,
Chromosomal translocations in human cancer.
1994,
Pubmed
Ravindranath,
Ganglioside GM3:GD3 ratio as an index for the management of melanoma.
1991,
Pubmed
Riordan,
Genetic and biochemical characterization of multidrug resistance.
1985,
Pubmed
Sato,
Effect of growth temperature on lipid and fatty acid compositions in the blue-green algae, Anabaena variabilis and Anacystis nidulans.
1979,
Pubmed
Sato,
Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity, DT-5461.
1995,
Pubmed
Suetake,
Human blood group B-active ganglio-glycosphingolipid in rat glioma.
1993,
Pubmed
Sugiyama,
Effects of various lysosphingolipids on cell growth, morphology and lipid composition in three neuroblastoma cell lines.
1990,
Pubmed
Takahashi,
Establishment of apoptosis-inducing monoclonal antibody 2D1 and 2D1-resistant variants of human T cell lines.
1993,
Pubmed
Taketomi,
Comparative studies on chemical, hemolytic and diffusion-in-gel precipitation properties of various lysosphingolipids.
1976,
Pubmed
Tsuruo,
Mechanisms of multidrug resistance and implications for therapy.
1988,
Pubmed
Uemura,
Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines.
1991,
Pubmed
Venditti,
The National Cancer Institute antitumor drug discovery program, current and future perspectives: a commentary.
1983,
Pubmed
Weis,
Regulation of epidermal growth factor receptor signal transduction. Role of gangliosides.
1990,
Pubmed
Yoshizawa,
Occurrence of cholesteryl sulfate in eggs of the sea urchin, Anthocidaris crassispina.
1974,
Pubmed
,
Echinobase
