ECB-ART-36019
J Med Chem
1994 Mar 18;376:793-7. doi: 10.1021/jm00032a012.
Show Gene links
Show Anatomy links
HIV-inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates.
???displayArticle.abstract???
A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values of 3-13 microM against HIV-1 (RF) and 2-8 microM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.
???displayArticle.pubmedLink??? 8145229
???displayArticle.link??? J Med Chem
Genes referenced: LOC100887844