Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2016 Apr 28;145:. doi: 10.3390/md14050086.
Show Gene links
Show Anatomy links
Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity.
Cui H
,
Liu Y
,
Nie Y
,
Liu Z
,
Chen S
,
Zhang Z
,
Lu Y
,
He L
,
Huang X
,
She Z
.
???displayArticle.abstract???
Four new polyketides: nectriacids A-C (1-3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), and macrocarpon C (7) were isolated from the culture of the endophytic fungus Nectria sp. HN001, which was isolated from a fresh branch of the mangrove plant Sonneratia ovata collected from the South China Sea. Their structures were determined by the detailed analysis of NMR and mass spectroscopic data. The absolute configuration of the stereogenic carbons for compound 4 was further assigned by Mosher''s ester method. All of the isolated compounds were tested for their α-glucosidase inhibitory activity by UV absorbance at 405 nm, and new compounds 2 and 3 exhibited potent inhibitory activity with IC50 values of 23.5 and 42.3 μM, respectively, which were more potent than positive control (acarbose, IC50, 815.3 μM).
American Diabetes Association,
Diagnosis and classification of diabetes mellitus.
2010, Pubmed
American Diabetes Association,
Diagnosis and classification of diabetes mellitus.
2010,
Pubmed
Bae,
Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.
2013,
Pubmed
Cui,
Potential antiviral lignans from the roots of Saururus chinensis with activity against Epstein-Barr virus lytic replication.
2014,
Pubmed
Gutiérrez,
Bioactive metabolites from the fungus Nectria galligena, the main apple canker agent in Chile.
2005,
Pubmed
,
Echinobase
Huang,
Asperterpenoid A, a new sesterterpenoid as an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B from the culture of Aspergillus sp. 16-5c.
2013,
Pubmed
Irvine,
Synthesis and characterization of synthetic analogs of cinnacidin, a novel phytotoxin from Nectria sp.
2008,
Pubmed
,
Echinobase
Kato,
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.
2012,
Pubmed
Li,
Exserolides A-F, new isocoumarin derivatives from the plant endophytic fungus Exserohilum sp.
2014,
Pubmed
Li,
Peniphenones A-D from the mangrove fungus Penicillium dipodomyicola HN4-3A as inhibitors of Mycobacterium tuberculosis phosphatase MptpB.
2014,
Pubmed
Liu,
Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1.
2015,
Pubmed
Liu,
Eurothiocin A and B, sulfur-containing benzofurans from a soft coral-derived fungus Eurotium rubrum SH-823.
2014,
Pubmed
Liu,
Nigerapyrones A-H, α-pyrone derivatives from the marine mangrove-derived endophytic fungus Aspergillus niger MA-132.
2011,
Pubmed
Mancini,
Crocetin, a carotenoid derived from saffron (Crocus sativus L.), improves acetylcholine-induced vascular relaxation in hypertension.
2014,
Pubmed
Nam,
Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells.
2010,
Pubmed
Ola,
Inducing secondary metabolite production by the endophytic fungus Fusarium tricinctum through coculture with Bacillus subtilis.
2013,
Pubmed
Parisot,
6-O-demethyl-5-deoxyfusarubin and its anhydro derivative produced by a mutant of the fungus Nectria haematococca blocked in fusarubin biosynthesis.
1991,
Pubmed
,
Echinobase
Pfander,
[Carotenoid-glycosides. Investigation of carotenoid-composition of saffron].
1975,
Pubmed
Rateb,
Secondary metabolites of fungi from marine habitats.
2011,
Pubmed
Schwenk,
Injury-induced biosynthesis of methyl-branched polyene pigments in a white-rotting basidiomycete.
2014,
Pubmed
Seco,
Absolute configuration of 1,n-diols by NMR: the importance of the combined anisotropic effects in bis-arylmethoxyacetates.
2000,
Pubmed
Seco,
Assignment of the absolute configuration of polyfunctional compounds by NMR using chiral derivatizing agents.
2012,
Pubmed
Wen,
Three metabolites from the mangrove endophytic fungus Sporothrix sp. (#4335) from the South China Sea.
2009,
Pubmed
Xiao,
Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242.
2013,
Pubmed
Xiao,
Asperlones A and B, dinaphthalenone derivatives from a mangrove endophytic fungus Aspergillus sp. 16-5C.
2015,
Pubmed
Zhang,
Biology and chemistry of endophytes.
2006,
Pubmed
