ECB-ART-36845
Biochem Biophys Res Commun
1998 Feb 04;2431:326-30. doi: 10.1006/bbrc.1997.7998.
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The effects of Ca2+ and Mg2+ on the major gelatinase activities present in the sea urchin embryo.
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We have examined the effects of Ca2+ and Mg2+ on the activities of the two most prominent gelatinases present in the developing sea urchin embryo. The EDTA-inhibited 41 kDa gelatinase was variously reactivated by concentrations of Mg2+ at or below 15 mM while the EDTA-inhibited 87 kDa gelatinase could not be reactivated by Mg2+. Magnesium partially inhibited the activities of both gelatinases and Ca2+ was protective against these inhibitory effects. In competition studies Mg2+ was shown to complete with Ca2+ for binding to the gelatinase. These results demonstrate competition between Ca2+ and Mg2+ for binding to and regulating the activities of these gelatinases in a marine environment which contains 10 mM Ca2+ and 50 mM Mg2+.
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Genes referenced: LOC100887844