ECB-ART-47920
Dev Comp Immunol
2003 Feb 01;272:105-10. doi: 10.1016/s0145-305x(02)00068-x.
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Lipopolysaccharides induce intestinal serum amyloid A expression in the sea cucumber Holothuria glaberrima.
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We have previously characterized the first invertebrate homolog of serum amyloid A (SAA) proteins in the sea cucumber Holothuria glaberrima, where its expression is associated with intestinal regeneration, suggesting a possible involvement of SAA proteins in intestinal morphogenesis. Here we show that bacterial lipopolysaccharides (LPS) trigger a coelomocyte-mediated immune response in H. glaberrima, inducing an approximately threefold increase in coelomocyte phagocytic activity. Furthermore, LPS induces an approximately fourfold increase in SAA mRNA levels in non-regenerating intestines. These results show that in H. glaberrima, LPS act as an immune activator and that SAA expression can be modulated by immune-associated processes.
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Genes referenced: LOC100887844 LOC590297