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J Asian Nat Prod Res 2017 May 01;195:474-480. doi: 10.1080/10286020.2016.1235038.
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Steroid glycosides from the starfish Pentaceraster gracilis.

Vien LT , Ngoan BT , Hanh TT , Vinh LB , Thung DC , Thao DT , Thanh NV , Cuong NX , Nam NH , Kiem PV , Minh CV .

Using combined chromatographic separations, two new steroid glycosides namely pentacerosides A (1) and B (2), and four known compounds were isolated from the methanol extract of the starfish Pentaceraster gracilis. Their structures were determined on the basis of spectroscopic data (1H and 13C NMR, HSQC, HMBC, 1H-1H COSY, ROESY, and FT-ICR-MS) and by comparing obtained results to the literature values. Among the isolated compounds, only maculatoside (5) showed significant cytotoxic effect against Hep-G2 (IC50 = 16.75 ± 0.69 μM) and SK-Mel2 (IC50 = 19.44 ± 1.45 μM) cell lines and moderate effect on KB (IC50 = 36.53 ± 0.78 μM), LNCaP (IC50 = 39.75 ± 3.34 μM), and MCF7 (IC50 = 47.34 ± 7.01 μM) cell lines.

PubMed ID: 27705003
Article link: J Asian Nat Prod Res

Genes referenced: LOC100893907 LOC115919910