Biochem Biophys Res Commun 1987 Jul 15;1461:284-90. doi: 10.1016/0006-291x(87)90723-6.

Inositol(1,3,4,5)tetrakisphosphate-induced activation of sea urchin eggs requires the presence of inositol trisphosphate.

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We have earlier reported that Inositol (1,3,4,5)tetrakisphosphate microinjection will activate eggs of the sea urchin Lytechinus variegatus provided that it is co-injected with inositol (2,4,5)trisphosphate (Irvine and Moor, Biochem. J. 240, 917-920, 1986). Here we extend these observations to show that inositol (1,3,4,5,6)pentakisphosphate is a partial agonist in this assay and the requirement for the presence of inositol (2,4,5)trisphosphate cannot be bypassed by raised, but sub-threshold, Ca2+ concentrations. A mechanism for the proposed stimulation of Ca2+ entry into the cell requiring both inositol tris- and tetrakisphosphates is presented.

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Genes referenced: LOC100887844 LOC115919910