Chollet L , Saboural P , Chauvierre C , Villemin JN , Letourneur D , Chaubet F .

	Figure 1. Evolution of published articles reporting fucoidans (from Web of Science). Left axis: number of articles for “Fucoidan*”, right axis: number of articles for “Fucoidan* + Nano*”.
	Figure 2. Repeating chemical structures of some fucoidans from brown algae (A) Chorda filum [28]; (B) Ascophyllum nodosum, Fucus vesiculosus, and Fucus evanescens [22,23,31] and from marine invertebrates: sea cucumber (Holothuriodea) (C) Ludwigothuria grisea [29]; (D) Strongylocentrotus droebachiensis [17], and (E) Strongylocentrotus franciscanus [30].

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Cumashi, A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds. 2007, Pubmed
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Desbrée, Evaluation of Functionalized Polysaccharide Microparticles Dosimetry for SPECT Imaging Based on Biodistribution Data of Rats. 2015, Pubmed
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Han, Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling. 2015, Pubmed
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Heeba, Fucoidan ameliorates steatohepatitis and insulin resistance by suppressing oxidative stress and inflammatory cytokines in experimental non-alcoholic fatty liver disease. 2015, Pubmed
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Kusaykin, Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds. 2008, Pubmed
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Lakshmana Senthil, Fucoidan - An α-amylase inhibitor from Sargassum wightii with relevance to NIDDM. 2015, Pubmed
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Lasky, Selectin-carbohydrate interactions and the initiation of the inflammatory response. 1995, Pubmed
Lauder, A fingerprinting method for chondroitin/dermatan sulfate and hyaluronan oligosaccharides. 2000, Pubmed
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Lee, Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment. 2013, Pubmed
Lee, Formation of chitosan-fucoidan nanoparticles and their electrostatic interactions: Quantitative analysis. 2016, Pubmed
Li, Fucoidan: structure and bioactivity. 2008, Pubmed
Li, Targeting P-selectin by gallium-68-labeled fucoidan positron emission tomography for noninvasive characterization of vulnerable plaques: correlation with in vivo 17.6T MRI. 2014, Pubmed
Li, Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy. 2016, Pubmed
Li, Degradation of sulfated polysaccharides from Enteromorpha prolifera and their antioxidant activities. 2013, Pubmed
Linhardt, Production and chemical processing of low molecular weight heparins. 1999, Pubmed
Lira, Cytotoxicity and cellular uptake of newly synthesized fucoidan-coated nanoparticles. 2011, Pubmed
Liu, Characterization of a heparan sulfate octasaccharide that binds to herpes simplex virus type 1 glycoprotein D. 2002, Pubmed
Liu, Fucoidan extract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells. 2012, Pubmed
Liu, Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC-HRMS-SPE-NMR. 2016, Pubmed
Liu, Lessons learned from the contamination of heparin. 2009, Pubmed
Lowe, Preparation and characterization of chitosan-natural nano hydroxyapatite-fucoidan nanocomposites for bone tissue engineering. 2016, Pubmed
Luo, Structure elucidation of a major fucopyranose-rich heteropolysaccharide (STP-II) from Sargassum thunbergii. 2016, Pubmed
Luyt, Low-molecular-weight fucoidan promotes therapeutic revascularization in a rat model of critical hindlimb ischemia. 2003, Pubmed
Lynch, The effect of dietary Laminaria-derived laminarin and fucoidan on nutrient digestibility, nitrogen utilisation, intestinal microflora and volatile fatty acid concentration in pigs. 2010, Pubmed
Mak, Fucoidan from New Zealand Undaria pinnatifida: monthly variations and determination of antioxidant activities. 2013, Pubmed
Martin, The Cultivable Surface Microbiota of the Brown Alga Ascophyllum nodosum is Enriched in Macroalgal-Polysaccharide-Degrading Bacteria. 2015, Pubmed
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