ECB-ART-43297
J Exp Biol
2014 Mar 01;217Pt 5:663-72. doi: 10.1242/jeb.086157.
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Established and potential physiological roles of bicarbonate-sensing soluble adenylyl cyclase (sAC) in aquatic animals.
Tresguerres M
,
Barott KL
,
Barron ME
,
Roa JN
.
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Soluble adenylyl cyclase (sAC) is a recently recognized source of the signaling molecule cyclic AMP (cAMP) that is genetically and biochemically distinct from the classic G-protein-regulated transmembrane adenylyl cyclases (tmACs). Mammalian sAC is distributed throughout the cytoplasm and it may be present in the nucleus and inside mitochondria. sAC activity is directly stimulated by HCO3(-), and sAC has been confirmed to be a HCO3(-) sensor in a variety of mammalian cell types. In addition, sAC can functionally associate with carbonic anhydrases to act as a de facto sensor of pH and CO2. The two catalytic domains of sAC are related to HCO3(-)-regulated adenylyl cyclases from cyanobacteria, suggesting the cAMP pathway is an evolutionarily conserved mechanism for sensing CO2 levels and/or acid/base conditions. Reports of sAC in aquatic animals are still limited but are rapidly accumulating. In shark gills, sAC senses blood alkalosis and triggers compensatory H(+) absorption. In the intestine of bony fishes, sAC modulates NaCl and water absorption. And in sea urchin sperm, sAC may participate in the initiation of flagellar movement and in the acrosome reaction. Bioinformatics and RT-PCR results reveal that sAC orthologs are present in most animal phyla. This review summarizes the current knowledge on the physiological roles of sAC in aquatic animals and suggests additional functions in which sAC may be involved.
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T32 GM067550 NIGMS NIH HHS
Genes referenced: adcy10 LOC100887844 LOC115919910 LOC590297 LOC752814
References [+] :
Acin-Perez,
Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation.
2009, Pubmed
Acin-Perez, Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation. 2009, Pubmed
Appukuttan, Type 10 adenylyl cyclase mediates mitochondrial Bax translocation and apoptosis of adult rat cardiomyocytes under simulated ischaemia/reperfusion. 2012, Pubmed
Barott, High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role. 2013, Pubmed
Beltrán, Particulate and soluble adenylyl cyclases participate in the sperm acrosome reaction. 2007, Pubmed , Echinobase
Bettice, The effects of hypocapnia on intracellular pH and bicarbonate. 1984, Pubmed
Bookbinder, Identification of sea urchin sperm adenylate cyclase. 1990, Pubmed , Echinobase
Bracho, Identification of flagellar proteins that initiate the activation of sperm motility in vivo. 1998, Pubmed , Echinobase
Braun, The effect of divalent cations on bovine spermatozoal adenylate cyclase activity. 1975, Pubmed
Braun, Evidence for multiple, cell specific, distinctive adenylate cyclase systems in rat testis. 1974, Pubmed
Braun, Purification of soluble form of adenylyl cyclase from testes. 1991, Pubmed
Braun, Inhibition of the soluble form of testis adenylate cyclase by catechol estrogens and other catechols. 1990, Pubmed
Braun, Development of a Mn-2+-sensitive, "soluble" adenylate cyclase in rat testis. 1975, Pubmed
Brown, Molecular mechanisms of acid-base sensing by the kidney. 2012, Pubmed
Buck, Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. 1999, Pubmed
Byrne, Ionic and acid-base consequences of exposure to increased salinity in the zebra mussel, Dreissena polymorpha. 2006, Pubmed
Carvalho, Water absorption and bicarbonate secretion in the intestine of the sea bream are regulated by transmembrane and soluble adenylyl cyclase stimulation. 2012, Pubmed
Chaloupka, Autoinhibitory regulation of soluble adenylyl cyclase. 2006, Pubmed
Chen, Role of soluble adenylyl cyclase in the heart. 2012, Pubmed
Chen, Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS. 2012, Pubmed
Chen, Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. 2000, Pubmed
Choi, Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase. 2012, Pubmed
Cooper, Regulation and organization of adenylyl cyclases and cAMP. 2003, Pubmed
Corredor, Soluble adenylyl cyclase activity is necessary for retinal ganglion cell survival and axon growth. 2012, Pubmed
Fabbri, Cyclic AMP signaling in bivalve molluscs: an overview. 2010, Pubmed
Farrell, Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice. 2008, Pubmed
Flacke, Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. 2013, Pubmed
Furla, Sources and mechanisms of inorganic carbon transport for coral calcification and photosynthesis. 2000, Pubmed
Garbers, The regulation of spermatozoa by calcium cyclic nucleotides. 1980, Pubmed
Geng, Cloning and characterization of the human soluble adenylyl cyclase. 2005, Pubmed
Gilmour, Type IV carbonic anhydrase is present in the gills of spiny dogfish (Squalus acanthias). 2007, Pubmed
Gong, Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. 2010, Pubmed
Grosell, Intestinal anion exchange in marine teleosts is involved in osmoregulation and contributes to the oceanic inorganic carbon cycle. 2011, Pubmed
Guillou, Inhibition by calcium of mammalian adenylyl cyclases. 1999, Pubmed
Gutowska, Acid-base regulatory ability of the cephalopod (Sepia officinalis) in response to environmental hypercapnia. 2010, Pubmed , Echinobase
Hanoune, Regulation and role of adenylyl cyclase isoforms. 2001, Pubmed
Hess, The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. 2005, Pubmed
Hobe, The mechanisms of acid-base and ionoregulation in the freshwater rainbow trout during environmental hyperoxia and subsequent normoxia. I. Extra- and intracellular acid-base status. 1984, Pubmed
Jaiswal, Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. 2003, Pubmed
Jaiswal, Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. 2001, Pubmed
Kamenetsky, Molecular details of cAMP generation in mammalian cells: a tale of two systems. 2006, Pubmed
Kolodecik, Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells. 2012, Pubmed
Kumar, Soluble adenylyl cyclase controls mitochondria-dependent apoptosis in coronary endothelial cells. 2009, Pubmed
Lannig, Impact of ocean acidification on energy metabolism of oyster, Crassostrea gigas--changes in metabolic pathways and thermal response. 2010, Pubmed
Lecuona, Protein kinase A-Iα regulates Na,K-ATPase endocytosis in alveolar epithelial cells exposed to high CO(2) concentrations. 2013, Pubmed
Lee, Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body. 2011, Pubmed
Linder, Class III adenylyl cyclases: molecular mechanisms of catalysis and regulation. 2006, Pubmed
Linder, Versatility of signal transduction encoded in dimeric adenylyl cyclases. 2008, Pubmed
Litvin, Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. 2003, Pubmed
Lomovatskaya, Detection of soluble adenylyl cyclase isoforms in plants. 2008, Pubmed
Lopes-Lima, Seasonal variations of pH, pCO2, pO2, HCO3- and Ca2+ in the haemolymph: implications on the calcification physiology in Anodonta cygnea. 2009, Pubmed
Magro, Soluble adenylyl cyclase antibody profile as a diagnostic adjunct in the assessment of pigmented lesions. 2012, Pubmed
Magro, Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins. 2012, Pubmed
Matsuda, Recent progresses on the genetic basis of the regulation of CO2 acquisition systems in response to CO2 concentration. 2011, Pubmed
Michaelidis, Extracellular and intracellular acid-base status with regard to the energy metabolism in the oyster Crassostrea gigas during exposure to air. 2005, Pubmed
Middelhaufe, Identification of a haem domain in human soluble adenylate cyclase. 2012, Pubmed
Moore, Soluble adenylyl cyclase is not required for axon guidance to netrin-1. 2008, Pubmed
Morisawa, Induction of potential for sperm motility by bicarbonate and pH in rainbow trout and chum salmon. 1988, Pubmed
Morisawa, Short-term changes in levels of cyclic AMP, adenylate cyclase, and phosphodiesterase during the initiation of sperm motility in rainbow trout. 1987, Pubmed
Nomura, A soluble adenylyl cyclase from sea urchin spermatozoa. 2005, Pubmed , Echinobase
Nomura, Proteins associated with soluble adenylyl cyclase in sea urchin sperm flagella. 2006, Pubmed , Echinobase
Pastor-Soler, Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. 2003, Pubmed
Pastor-Soler, Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. 2008, Pubmed
Paunescu, Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells. 2008, Pubmed
Piermarini, Pendrin immunoreactivity in the gill epithelium of a euryhaline elasmobranch. 2002, Pubmed
Ramos, Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells. 2008, Pubmed
Richards, Exercise and recovery metabolism in the Pacific spiny dogfish (Squalus acanthias). 2003, Pubmed
Roelofs, Deducing the origin of soluble adenylyl cyclase, a gene lost in multiple lineages. 2002, Pubmed
Romanenko, Intracellular localization of "soluble" adenylate cyclase in potato plants. 2008, Pubmed
Schmid, Decreased soluble adenylyl cyclase activity in cystic fibrosis is related to defective apical bicarbonate exchange and affects ciliary beat frequency regulation. 2010, Pubmed
Seamon, Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. 1981, Pubmed
Seamon, Forskolin: a unique diterpene activator of cyclic AMP-generating systems. 1981, Pubmed
Shuttleworth, A critical analysis of carbonic anhydrase function, respiratory gas exchange, and the acid-base control of secretion in the rectal gland of Squalus acanthias. 2006, Pubmed
Steegborn, A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. 2005, Pubmed
Steegborn, Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment. 2005, Pubmed
Strobel, Metabolic shifts in the Antarctic fish Notothenia rossii in response to rising temperature and PCO2. 2012, Pubmed
Tresguerres, Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. 2010, Pubmed
Tresguerres, Regulation of branchial V-H(+)-ATPase, Na(+)/K(+)-ATPase and NHE2 in response to acid and base infusions in the Pacific spiny dogfish (Squalus acanthias). 2005, Pubmed
Tresguerres, Microtubule-dependent relocation of branchial V-H+-ATPase to the basolateral membrane in the Pacific spiny dogfish (Squalus acanthias): a role in base secretion. 2006, Pubmed
Tresguerres, Physiological carbon dioxide, bicarbonate, and pH sensing. 2010, Pubmed
Tresguerres, Intracellular cAMP signaling by soluble adenylyl cyclase. 2011, Pubmed
Tresguerres, V-H+ -ATPase translocation during blood alkalosis in dogfish gills: interaction with carbonic anhydrase and involvement in the postfeeding alkaline tide. 2007, Pubmed
Tresguerres, Chloride uptake and base secretion in freshwater fish: a transepithelial ion-transport metabolon? 2006, Pubmed
Tresguerres, Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclase. 2010, Pubmed
Valbonesi, Modulation of adenyl cyclase activity in the gills of Tapes philippinarum. 2004, Pubmed
Walsh, Metabolic organization and effects of feeding on enzyme activities of the dogfish shark (Squalus acanthias) rectal gland. 2006, Pubmed
Wang, The respiratory consequences of feeding in amphibians and reptiles. 2001, Pubmed
Wang, Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system. 2003, Pubmed
Willoughby, Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains. 2007, Pubmed
Wilson, Intestinal bicarbonate secretion by marine teleost fish--why and how? 2002, Pubmed
Wilson, Contribution of fish to the marine inorganic carbon cycle. 2009, Pubmed
Wong, AKAP signalling complexes: focal points in space and time. 2004, Pubmed
Wood, Is the alkaline tide a signal to activate metabolic or ionoregulatory enzymes in the dogfish shark (Squalus acanthias)? 2008, Pubmed
Wood, Control of rectal gland secretion by blood acid-base status in the intact dogfish shark (Squalus acanthias). 2007, Pubmed
Wood, Control of ventilation in the hypercapnic skate Raja ocellata: II. Cerebrospinal fluid and intracellular pH in the brain and other tissues. 1990, Pubmed
Wood, The alkaline tide goes out and the nitrogen stays in after feeding in the dogfish shark, Squalus acanthias. 2007, Pubmed
Wood, Alkaline tide and nitrogen conservation after feeding in an elasmobranch (Squalus acanthias). 2005, Pubmed
Wood, Using omeprazole to link the components of the post-prandial alkaline tide in the spiny dogfish, Squalus acanthias. 2009, Pubmed
Zaccolo, Restricted diffusion of a freely diffusible second messenger: mechanisms underlying compartmentalized cAMP signalling. 2006, Pubmed
Zaccolo, cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. 2009, Pubmed
Zhu, A large-scale analysis of mRNAs expressed by primary mesenchyme cells of the sea urchin embryo. 2001, Pubmed , Echinobase
Zilli, Molecular mechanisms determining sperm motility initiation in two sparids (Sparus aurata and Lithognathus mormyrus). 2008, Pubmed
Zippin, Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. 2010, Pubmed
Zippin, Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. 2003, Pubmed
Zippin, Bicarbonate-responsive "soluble" adenylyl cyclase defines a nuclear cAMP microdomain. 2004, Pubmed