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Biol Lett
2016 Feb 01;122:20151057. doi: 10.1098/rsbl.2015.1057.
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Induction of innate immune gene expression following methyl methanesulfonate-induced DNA damage in sea urchins.
Reinardy HC
,
Chapman J
,
Bodnar AG
.
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Sea urchins are noted for the absence of neoplastic disease and represent a novel model to investigate cellular and systemic cancer protection mechanisms. Following intracoelomic injection of the DNA alkylating agent methyl methanesulfonate, DNA damage was detected in sea urchin cells and tissues (coelomocytes, muscle, oesophagus, ampullae and gonad) by the alkaline unwinding, fast micromethod. Gene expression analyses of the coelomocytes indicated upregulation of innate immune markers, including genes involved in NF-κB signalling. Results suggest that activation of the innate immune system following DNA damage may contribute to the naturally occurring resistance to neoplastic disease observed in sea urchins.
Baldwin,
The NF-kappa B and I kappa B proteins: new discoveries and insights.
1996, Pubmed
Baldwin,
The NF-kappa B and I kappa B proteins: new discoveries and insights.
1996,
Pubmed
Buckley,
Dynamic evolution of toll-like receptor multigene families in echinoderms.
2012,
Pubmed
,
Echinobase
El-Bibany,
Comparative DNA damage and repair in echinoderm coelomocytes exposed to genotoxicants.
2014,
Pubmed
,
Echinobase
Ermolaeva,
DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.
2013,
Pubmed
Ferguson,
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
2012,
Pubmed
Gasser,
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor.
2005,
Pubmed
Ghosh,
Sp185/333: a novel family of genes and proteins involved in the purple sea urchin immune response.
2010,
Pubmed
,
Echinobase
Hibino,
The immune gene repertoire encoded in the purple sea urchin genome.
2006,
Pubmed
,
Echinobase
Hoeijmakers,
DNA repair mechanisms.
2001,
Pubmed
Ju,
Gadd45b and Gadd45g are important for anti-tumor immune responses.
2009,
Pubmed
Khudoley,
Tumor induction by N-nitroso compounds in bivalve mollusks Unio pictorum.
1978,
Pubmed
McAloose,
Wildlife cancer: a conservation perspective.
2009,
Pubmed
Moskalev,
Gadd45 proteins: relevance to aging, longevity and age-related pathologies.
2012,
Pubmed
Pfaffl,
A new mathematical model for relative quantification in real-time RT-PCR.
2001,
Pubmed
Reinardy,
Tissue regeneration and biomineralization in sea urchins: role of Notch signaling and presence of stem cell markers.
2015,
Pubmed
,
Echinobase
Reinardy,
Profiling DNA damage and repair capacity in sea urchin larvae and coelomocytes exposed to genotoxicants.
2015,
Pubmed
,
Echinobase
Robert,
Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates.
2010,
Pubmed
Schröder,
Fast micromethod DNA single-strand-break assay.
2006,
Pubmed
Van Beneden,
Molecular analysis of bivalve tumors: models for environmental/genetic interactions.
1994,
Pubmed
Wu,
Many faces of NF-kappaB signaling induced by genotoxic stress.
2007,
Pubmed
Wyatt,
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks.
2006,
Pubmed
