ECB-ART-48075
Semin Cell Dev Biol
2001 Feb 01;121:45-51. doi: 10.1006/scdb.2000.0216.
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Ca2+ signalling during fertilization of echinoderm eggs.
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The Ca2+ rise at fertilization of echinoderm eggs is initiated by a process requiring the sequential activation of a Src family kinase, phospholipase C gamma, and the inositol trisphosphate receptor/channel in the endoplasmic reticulum. The consequences of the Ca2+ rise include exocytosis of cortical granules, which establishes a block to polyspermy, and inactivation of MAP kinase, which functions in linking the Ca2+ rise to the reinitiation of the cell cycle.
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Genes referenced: LOC115919910 LOC574936 LOC583807 SFK1