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ECB-ART-35850
J Nat Prod 1994 Nov 01;5711:1591-4. doi: 10.1021/np50113a023.
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Inhibitors of protein tyrosine kinase pp60v-src: sterol sulfates from the brittle star Ophiarachna incrassata.

Fu X , Schmitz FJ , Lee RH , Papkoff JS , Slate DL .


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Bioactivity-guided fractionation of the extracts of the green brittle star Ophiarachna incrassata using a protein tyrosine kinase pp60v-src inhibition assay led to the isolation of a new sterol sulfate [2] together with four known ones (1,3-5). All five compounds were found to inhibit protein tyrosine kinase pp 60v-src.

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Genes referenced: LOC574936