Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Dev Genes Evol
2009 Feb 01;2192:79-87. doi: 10.1007/s00427-009-0271-2.
Show Gene links
Show Anatomy links
Conserved and novel gene expression between regeneration and asexual fission in Nematostella vectensis.
Burton PM
,
Finnerty JR
.
Abstract
Due to work in model systems (e.g., flies and mice), the molecular mechanisms of embryogenesis are known in exquisite detail. However, these organisms are incapable of asexual reproduction and possess limited regenerative abilities. Thus, the mechanisms of alternate developmental trajectories and their relation to embryonic mechanisms remain understudied. Because these developmental trajectories are present in a diverse group of animal phyla spanning the metazoan phylogeny, including cnidarians, annelids, and echinoderms, they are likely to have played a major role in animal evolution. The starlet sea anemone Nematostella vectensis, an emerging model system, undergoes larval development, asexual fission, and complete bi-directional regeneration in the field and laboratory. In order to investigate to what extent embryonic patterning mechanisms are utilized during alternate developmental trajectories, we examined expression of developmental regulatory genes during regeneration and fission. When compared to previously reported embryonic expression patterns, we found that all genes displayed some level of expression consistent with embryogenesis. However, five of seven genes investigated also displayed striking differences in gene expression between one or more developmental trajectory. These results demonstrate that alternate developmental trajectories utilize distinct molecular mechanisms upstream of major developmental regulatory genes such as fox, otx, and Hox-like.
Beck,
Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate.
2003, Pubmed
Beck,
Molecular pathways needed for regeneration of spinal cord and muscle in a vertebrate.
2003,
Pubmed
Bely,
Evolution of regeneration and fission in annelids: insights from engrailed- and orthodenticle-class gene expression.
2001,
Pubmed
Bode,
Head regeneration in Hydra.
2003,
Pubmed
Broun,
Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra.
1999,
Pubmed
Callaerts,
Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina.
1999,
Pubmed
Chourrout,
Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements.
2006,
Pubmed
Christen,
Regeneration-specific expression pattern of three posterior Hox genes.
2003,
Pubmed
Darling,
Rising starlet: the starlet sea anemone, Nematostella vectensis.
2005,
Pubmed
Finnerty,
The origins of axial patterning in the metazoa: how old is bilateral symmetry?
2003,
Pubmed
Finnerty,
Early evolution of a homeobox gene: the parahox gene Gsx in the Cnidaria and the Bilateria.
2003,
Pubmed
Finnerty,
Origins of bilateral symmetry: Hox and dpp expression in a sea anemone.
2004,
Pubmed
Fröbius,
Expression of developmental genes during early embryogenesis of Hydra.
2003,
Pubmed
Galliot,
Cnidarians as a model system for understanding evolution and regeneration.
2002,
Pubmed
Gauchat,
Evolution of Antp-class genes and differential expression of Hydra Hox/paraHox genes in anterior patterning.
2000,
Pubmed
Genikhovich,
Discovery of genes expressed in Hydra embryogenesis.
2006,
Pubmed
Gont,
Tail formation as a continuation of gastrulation: the multiple cell populations of the Xenopus tailbud derive from the late blastopore lip.
1993,
Pubmed
Hand,
The Culture, Sexual and Asexual Reproduction, and Growth of the Sea Anemone Nematostella vectensis.
1992,
Pubmed
Handberg-Thorsager,
The planarian nanos-like gene Smednos is expressed in germline and eye precursor cells during development and regeneration.
2007,
Pubmed
Hobmayer,
WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra.
2000,
Pubmed
Lin,
Regeneration of neural crest derivatives in the Xenopus tadpole tail.
2007,
Pubmed
Martindale,
Investigating the origins of triploblasty: 'mesodermal' gene expression in a diploblastic animal, the sea anemone Nematostella vectensis (phylum, Cnidaria; class, Anthozoa).
2004,
Pubmed
Martinez,
Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra.
1997,
Pubmed
Masuda-Nakagawa,
The HOX-like gene Cnox2-Pc is expressed at the anterior region in all life cycle stages of the jellyfish Podocoryne carnea.
2000,
Pubmed
Mazza,
Genomic organization, gene structure, and developmental expression of three clustered otx genes in the sea anemone Nematostella vectensis.
2007,
Pubmed
Mochizuki,
Expression and evolutionary conservation of nanos-related genes in Hydra.
2000,
Pubmed
Orii,
The planarian HOM/HOX homeobox genes (Plox) expressed along the anteroposterior axis.
1999,
Pubmed
Reddien,
Fundamentals of planarian regeneration.
2004,
Pubmed
Reddien,
SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells.
2005,
Pubmed
Reinhardt,
HyBMP5-8b, a BMP5-8 orthologue, acts during axial patterning and tentacle formation in hydra.
2004,
Pubmed
Rossi,
DjPiwi-1, a member of the PAZ-Piwi gene family, defines a subpopulation of planarian stem cells.
2006,
Pubmed
Ryan,
The cnidarian-bilaterian ancestor possessed at least 56 homeoboxes: evidence from the starlet sea anemone, Nematostella vectensis.
2006,
Pubmed
Saló,
The power of regeneration and the stem-cell kingdom: freshwater planarians (Platyhelminthes).
2006,
Pubmed
Sánchez Alvarado,
Planarian regeneration: its end is its beginning.
2006,
Pubmed
Shenk,
Expression of Cnox-2, a HOM/HOX gene, is suppressed during head formation in hydra.
1993,
Pubmed
Shenk,
Expression of Cnox-2, a HOM/HOX homeobox gene in hydra, is correlated with axial pattern formation.
1993,
Pubmed
Smith,
CnOtx, a member of the Otx gene family, has a role in cell movement in hydra.
1999,
Pubmed
Sugiura,
Differential gene expression between the embryonic tail bud and regenerating larval tail in Xenopus laevis.
2004,
Pubmed
Technau,
HyBra1, a Brachyury homologue, acts during head formation in Hydra.
1999,
Pubmed
Wang,
nanos function is essential for development and regeneration of planarian germ cells.
2007,
Pubmed
Whitehead,
fgf20 is essential for initiating zebrafish fin regeneration.
2005,
Pubmed
Yanze,
Conservation of Hox/ParaHox-related genes in the early development of a cnidarian.
2001,
Pubmed
