ECB-ART-31931
Biochim Biophys Acta
1985 Apr 19;8244:349-56. doi: 10.1016/0167-4781(85)90042-9.
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RNA synthesis in male pronuclei of the sea urchin.
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Transcription in male pronuclei of fertilized sea urchin eggs was measured by comparison of [3H]uridine incorporation into RNA in polyspermic, monospermic and activated eggs under conditions where uptake of the isotope and conversion to UTP were equivalent. RNA accumulation from male pronuclei begins by S phase of the first cell cycle. Initiation of this RNA synthesis does not require DNA synthesis. A major fraction of the newly synthesized transcripts are mRNAs coding for early embryo (alpha-) histones. In addition, several other unidentified transcripts are detected by gel electrophoresis. The pattern of RNA transcription remains constant for at least 4 h post-fertilization. These results demonstrate that specific transcription of male pronuclear sequences is activated in the first cell cycle following fertilization.
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Genes referenced: LOC100887844 LOC115919910