Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Echinobase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Science 2002 Mar 01;2955560:1669-78. doi: 10.1126/science.1069883.
Show Gene links Show Anatomy links

A genomic regulatory network for development.

Davidson EH , Rast JP , Oliveri P , Ransick A , Calestani C , Yuh CH , Minokawa T , Amore G , Hinman V , Arenas-Mena C , Otim O , Brown CT , Livi CB , Lee PY , Revilla R , Rust AG , Pan Zj , Schilstra MJ , Clarke PJ , Arnone MI , Rowen L , Cameron RA , McClay DR , Hood L , Bolouri H .

Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.

PubMed ID: 11872831
Article link: Science
Grant support: [+]

Genes referenced: LOC100887844 LOC115925415