Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
Mar Drugs
2019 Jan 04;171:. doi: 10.3390/md17010026.
Show Gene links
Show Anatomy links
Capillasterin A, a Novel Pyrano[2,3-f]chromene from the Australian Crinoid Capillaster multiradiatus.
Lum KY
,
Carroll AR
,
Ekins MG
,
Read S
,
Haq Z
,
Tietjen I
,
St John J
,
Davis RA
.
???displayArticle.abstract???
Capillasterin A (1), a novel pyrano[2,3-f]chromene, together with seven known naphthopyrones including comaparvin (2), TMC-256C1 (3), 6-methoxycomaparvin-5- methyl ether (4), 5,8-dihydroxy-6-methoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (5), 5,8-dihydroxy-6,10-dimethoxy-2-propyl-4H-naphtho[2,3-b]pyran-4-one (6), TMC-256A1 (7) and 6-methoxycomaparvin (8) were isolated from an EtOH/H₂O extract from the Australian crinoid Capillaster multiradiatus. The structures of all the compounds were determined by detailed spectroscopic (1D/2D NMR and MS) data analysis. This is the first report of a natural product that contains the pyrano[2,3-f]chromene skeleton. Compounds 2⁻6 were observed to display moderate inhibition of in vitro HIV-1 replication in a T cell line with EC50 values ranging from 7.5 to 25.5 µM without concomitant cytotoxicity.
Adachi,
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
1986, Pubmed
Adachi,
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
1986,
Pubmed
Bokesch,
Inhibition of ABCG2-mediated drug efflux by naphthopyrones from marine crinoids.
2010,
Pubmed
,
Echinobase
Brockman,
Use of a novel GFP reporter cell line to examine replication capacity of CXCR4- and CCR5-tropic HIV-1 by flow cytometry.
2006,
Pubmed
Chen,
Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid Comanthus bennetti.
2014,
Pubmed
,
Echinobase
Chen,
The serrulatane diterpenoid natural products RAD288 and RAD289 stimulate properties of olfactory ensheathing cells useful for neural repair therapies.
2018,
Pubmed
Chovolou,
Identification of angular naphthopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-κB signaling pathway.
2011,
Pubmed
,
Echinobase
FOLEY,
CONTINUOUS CULTURE OF HUMAN LYMPHOBLASTS FROM PERIPHERAL BLOOD OF A CHILD WITH ACUTE LEUKEMIA.
1965,
Pubmed
Feng,
Crinoids: ancient organisms, modern chemistry.
2017,
Pubmed
Folmer,
NF-kappaB-inhibiting naphthopyrones from the Fijian echinoderm Comanthus parvicirrus.
2008,
Pubmed
,
Echinobase
Frandsen,
The biosynthetic pathway for aurofusarin in Fusarium graminearum reveals a close link between the naphthoquinones and naphthopyrones.
2006,
Pubmed
Khokhar,
Rhodocomatulin-Type Anthraquinones from the Australian Marine Invertebrates Clathria hirsuta and Comatula rotalaria.
2016,
Pubmed
,
Echinobase
Levrier,
6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells.
2017,
Pubmed
Richard,
Identification of Novel HIV-1 Latency-Reversing Agents from a Library of Marine Natural Products.
2018,
Pubmed
Sakurai,
TMC-256A1 and C1, new inhibitors of IL-4 signal transduction produced by Aspergillus niger var niger TC 1629.
2002,
Pubmed
Staunton,
Polyketide biosynthesis: a millennium review.
2001,
Pubmed
Summers,
Phylogeny of Comatulidae (Echinodermata: Crinoidea: Comatulida): a new classification and an assessment of morphological characters for crinoid taxonomy.
2014,
Pubmed
,
Echinobase
Tietjen,
Inhibition of NF-κB-dependent HIV-1 replication by the marine natural product bengamide A.
2018,
Pubmed
Tietjen,
Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.
2015,
Pubmed
Vien,
Anthraquinone and Butenolide Constituents from the Crinoid Capillaster multiradiatus.
2018,
Pubmed
,
Echinobase
Wolkenstein,
Persistent and widespread occurrence of bioactive quinone pigments during post-Paleozoic crinoid diversification.
2015,
Pubmed
,
Echinobase
Wätjen,
Cytotoxic effects of the anthraquinone derivatives 1'-deoxyrhodoptilometrin and (S)-(-)-rhodoptilometrin isolated from the marine echinoderm Comanthus sp.
2017,
Pubmed
,
Echinobase
Zulfiqar,
Screening a Natural Product-Based Library against Kinetoplastid Parasites.
2017,
Pubmed
