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ECB-ART-45771
Nat Prod Res 2018 May 01;329:1039-1043. doi: 10.1080/14786419.2017.1378206.
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Triterpene tetraglycosides from the sea cucumber Stichopus horrens.

Vien LT , Hoang L , Hanh TTH , Thanh NV , Cuong NX , Nam NH , Thung DC , Kiem PV , Minh CV .


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Using various chromatographic separations, three triterpene tetraglycosides (1-3), including one new compound, namely stichorrenoside E (1) along with thelenotoside B (2) and deacetyl thelenotoside B (3), were isolated from the MeOH extract of the Vietnamese sea cucumber Stichopus horrens. Their structures were confirmed by spectroscopic experiments, such as 1D and 2D NMR and HR-ESI-MS. Deacetylated thelenotoside B (3) is firstly isolated as a natural product. Among these compounds, thelenotoside B (2) showed strong cytotoxicities against five human cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK-Mel2 with the IC50 values from 0.95 ± 0.08 to 1.90 ± 0.13 μM, whereas stichorrenoside E (1) and deacetyl thelenotoside B (3) exhibited significant activities with the IC50 values from 6.87 ± 0.25 to 11.62 ± 1.05 μM.

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Genes referenced: LOC100887844 LOC100893907 LOC115919910 LOC593824