ECB-ART-41651
Bioorg Med Chem Lett
2010 Jun 15;2012:3826-30. doi: 10.1016/j.bmcl.2010.04.005.
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Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.
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New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.
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Genes referenced: LOC100893907 LOC115919910 LOC593824