Click
here to close Hello! We notice that
you are using Internet Explorer, which is not supported by Echinobase
and may cause the site to display incorrectly. We suggest using a
current version of Chrome,
FireFox,
or Safari.
In vitro fracture testing of submicron diameter collagen fibril specimens.
Shen ZL
,
Dodge MR
,
Kahn H
,
Ballarini R
,
Eppell SJ
.
???displayArticle.abstract???
Mechanical testing of collagenous tissues at different length scales will provide improved understanding of the mechanical behavior of structures such as skin, tendon, and bone, and also guide the development of multiscale mechanical models. Using a microelectromechanical-systems (MEMS) platform, stress-strain response curves up to failure of type I collagen fibril specimens isolated from the dermis of sea cucumbers were obtained in vitro. A majority of the fibril specimens showed brittle fracture. Some displayed linear behavior up to failure, while others displayed some nonlinearity. The fibril specimens showed an elastic modulus of 470 ± 410 MPa, a fracture strength of 230 ± 160 MPa, and a fracture strain of 80% ± 44%. The fibril specimens displayed significantly lower elastic modulus in vitro than previously measured in air. Fracture strength/strain obtained in vitro and in air are both significantly larger than those obtained in vacuo, indicating that the difference arises from the lack of intrafibrillar water molecules produced by vacuum drying. Furthermore, fracture strength/strain of fibril specimens were different from those reported for collagenous tissues of higher hierarchical levels, indicating the importance of obtaining these properties at the fibrillar level for multiscale modeling.
Bella,
Crystal and molecular structure of a collagen-like peptide at 1.9 A resolution.
1994, Pubmed
Bella,
Crystal and molecular structure of a collagen-like peptide at 1.9 A resolution.
1994,
Pubmed
Buehler,
Nature designs tough collagen: explaining the nanostructure of collagen fibrils.
2006,
Pubmed
Buehler,
Entropic elasticity controls nanomechanics of single tropocollagen molecules.
2007,
Pubmed
Buehler,
Nanomechanics of collagen fibrils under varying cross-link densities: atomistic and continuum studies.
2008,
Pubmed
Chimich,
Water content alters viscoelastic behaviour of the normal adolescent rabbit medial collateral ligament.
1992,
Pubmed
Derwin,
A quantitative investigation of structure-function relationships in a tendon fascicle model.
1999,
Pubmed
Eppell,
Nano measurements with micro-devices: mechanical properties of hydrated collagen fibrils.
2006,
Pubmed
Fullerton,
Evidence that collagen and tendon have monolayer water coverage in the native state.
2006,
Pubmed
Fullerton,
An NMR method to characterize multiple water compartments on mammalian collagen.
2006,
Pubmed
Gautieri,
Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains.
2009,
Pubmed
Gautieri,
Molecular and mesoscale mechanisms of osteogenesis imperfecta disease in collagen fibrils.
2009,
Pubmed
Gautieri,
Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules.
2009,
Pubmed
Graham,
Structural changes in human type I collagen fibrils investigated by force spectroscopy.
2004,
Pubmed
Grant,
Tuning the elastic modulus of hydrated collagen fibrils.
2009,
Pubmed
Gupta,
Cooperative deformation of mineral and collagen in bone at the nanoscale.
2006,
Pubmed
Harley,
Phonons and the elastic moduli of collagen and muscle.
1977,
Pubmed
Haut,
The state of tissue hydration determines the strain-rate-sensitive stiffness of human patellar tendon.
1997,
Pubmed
Heim,
Low strain nanomechanics of collagen fibrils.
2007,
Pubmed
Hoffman,
Determining the effect of hydration upon the properties of ligaments using pseudo Gaussian stress stimuli.
2005,
Pubmed
Kadler,
Collagen fibril formation.
1996,
Pubmed
Leikin,
Direct measurement of forces between self-assembled proteins: temperature-dependent exponential forces between collagen triple helices.
1994,
Pubmed
Leikin,
Raman spectral evidence for hydration forces between collagen triple helices.
1997,
Pubmed
Misof,
A new molecular model for collagen elasticity based on synchrotron X-ray scattering evidence.
1997,
Pubmed
Naraghi,
Novel method for mechanical characterization of polymeric nanofibers.
2007,
Pubmed
Puxkandl,
Viscoelastic properties of collagen: synchrotron radiation investigations and structural model.
2002,
Pubmed
Ramachandran,
Interchain hydrogen bonds via bound water molecules in the collagen triple helix.
1968,
Pubmed
Sasaki,
Elongation mechanism of collagen fibrils and force-strain relations of tendon at each level of structural hierarchy.
1996,
Pubmed
Screen,
An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
2004,
Pubmed
Shen,
Stress-strain experiments on individual collagen fibrils.
2008,
Pubmed
,
Echinobase
Tang,
Deformation micromechanisms of collagen fibrils under uniaxial tension.
2010,
Pubmed
Thornton,
Altering ligament water content affects ligament pre-stress and creep behaviour.
2001,
Pubmed
Wenger,
Mechanical properties of collagen fibrils.
2007,
Pubmed
Yamamoto,
Mechanical properties of collagen fascicles from the rabbit patellar tendon.
1999,
Pubmed
Yang,
Micromechanical bending of single collagen fibrils using atomic force microscopy.
2007,
Pubmed
Yang,
Mechanical properties of native and cross-linked type I collagen fibrils.
2008,
Pubmed
van der Rijt,
Micromechanical testing of individual collagen fibrils.
2006,
Pubmed
