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Echinobase
ECB-ART-36842
Dev Biol 1998 Jan 15;1932:139-45. doi: 10.1006/dbio.1997.8802.
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Structure and function of a sea urchin orthodenticle-related gene (HpOtx).

Kiyama T , Akasaka K , Takata K , Mitsunaga-Nakatsubo K , Sakamoto N , Shimada H .


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Two distinct types of orthodenticle-related proteins (HpOtxE/L) have been implicated as transcription activators of the aboral ectoderm-specific arylsulfatase (Ars) gene. Here, we describe the structure of HpOtx gene and present evidence that mRNAs of HpOtxE/L are transcribed from a single HpOtx gene by altering the transcription start site and by alternative splicing. By transactivation experiments, we have also demonstrated that HpOtxL activates the Ars promoter in the gastrula-stage embryo.

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Genes referenced: arsal LOC100887844 LOC575336